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Japanese Journal of Clinical Oncology 32:210-214 (2002)
© 2002 Foundation for Promotion of Cancer Research

Aggressive Undifferentiated Carcinoma of Unknown Primary Site Complicated by Lactic Acidosis After Bleeding: a Case Report

Wing Keung Chau1,4, Ching Fen Yang2,4, Yi Hong Chou3,4 and Chao Hung Ho1,4,+

1 Division of Hematology, Department of Medicine, 2 Department of Pathology and 3 Department of Radiology, Taipei Veterans General Hospital and 4 National Yang-Ming University School of Medicine, Taipei, Taiwan

Undifferentiated carcinoma of unknown primary site complicated by lactic acidosis has not been documented. We describe a young female with undifferentiated carcinoma of unknown primary site manifested by widespread lymph node and hepatic infiltration, hyperuricemia and very high levels of lactate dehydrogenase. She developed lactic acidosis suddenly after an episode of bleeding following nasal biopsy. The bleeding episode is likely to have caused subclinical hepatic hypoperfusion and hypoxemia, thereby aggravating lactate overproduction by tumor cells and clearance impairment due to diffuse hepatic infiltration to result in rapidly fatal acidosis before cytotoxic agents could be instituted. Although uncommon, when a critical event occurs in aggressive malignancies with massive hepatic involvement, the clinician should be alert for the development of lactic acidosis because the life-threatening metabolic complication is best avoided by prompt and effective cytoreduction therapy.

+ For reprints and all correspondence: W. K. Chau, Division of Hematology, Department of Medicine, Taipei Veterans General Hospital, 201, Sec. 2, Shih-Pai Road, Taipei 112, Taiwan. E-mail: wkchau@vghtpe.gov.tw


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