Skip Navigation

This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (8)
Right arrow Request Permissions
Google Scholar
Right arrow Articles by Takano, T.
Right arrow Articles by Amino, N.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Takano, T.
Right arrow Articles by Amino, N.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Japanese Journal of Clinical Oncology 32:229-232 (2002)
© 2002 Foundation for Promotion of Cancer Research

Quantitative Analysis of Thymosin Beta-10 Messenger RNA in Thyroid Carcinomas

Toru Takano1, Yukiko Hasegawa1, Akira Miyauchi2, Fumio Matsuzuka2, Hiroshi Yoshida2, Kanji Kuma2 and Nobuyuki Amino1,+

1 Department of Laboratory Medicine, Osaka University Medical School, Suita, Osaka and 2 Kuma Hospital, Kobe, Japan

Background: Genes that are differentially expressed in benign and malignant tissues are important for the establishment of molecular-based diagnosis of carcinomas. Our recent study on the gene expression profile of thyroid carcinomas revealed an increased expression of thymosin beta-10 mRNA.

Methods: To confirm this, we measured the expression levels of thymosin beta-10 mRNA in 84 thyroid benign and malignant thyroid tissues, including five anaplastic carcinomas, by means of real-time quantitative reverse transcription-polymerase chain reaction.

Results: We found an increased expression of thymosin beta-10 mRNA in thyroid carcinomas, especially in anaplastic carcinomas. Expression levels of thymosin beta-10 mRNA relative to thyroglobulin mRNA in anaplastic carcinomas were greatly increased compared with those in differentiated carcinomas.

Conclusion: These results suggest the usefulness of the quantitative measurement of thymosin beta-10 mRNA in molecular-based diagnosis of thyroid anaplastic carcinomas, but not of differentiated carcinomas.

+ For reprints and all correspondence: Toru Takano, Department of Laboratory Medicine, Osaka University Medical School, D2, 2–2, Yamadaoka, Suita, Osaka 565-0871, Japan. E-mail: ttakano@labo.med.osaka-u.ac.jp


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Jpn J Clin OncolHome page
T. Takano, Y. Ito, F. Matsuzuka, A. Miya, K. Kobayashi, H. Yoshida, and A. Miyauchi
Expression of Oncofetal Fibronectin mRNA in Thyroid Anaplastic Carcinoma
Jpn. J. Clin. Oncol., September 1, 2007; 37(9): 647 - 651.
[Abstract] [Full Text] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.