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Japanese Journal of Clinical Oncology 32:229-232 (2002)
© 2002 Foundation for Promotion of Cancer Research

Quantitative Analysis of Thymosin Beta-10 Messenger RNA in Thyroid Carcinomas

Toru Takano1, Yukiko Hasegawa1, Akira Miyauchi2, Fumio Matsuzuka2, Hiroshi Yoshida2, Kanji Kuma2 and Nobuyuki Amino1,+

1 Department of Laboratory Medicine, Osaka University Medical School, Suita, Osaka and 2 Kuma Hospital, Kobe, Japan

Background: Genes that are differentially expressed in benign and malignant tissues are important for the establishment of molecular-based diagnosis of carcinomas. Our recent study on the gene expression profile of thyroid carcinomas revealed an increased expression of thymosin beta-10 mRNA.

Methods: To confirm this, we measured the expression levels of thymosin beta-10 mRNA in 84 thyroid benign and malignant thyroid tissues, including five anaplastic carcinomas, by means of real-time quantitative reverse transcription-polymerase chain reaction.

Results: We found an increased expression of thymosin beta-10 mRNA in thyroid carcinomas, especially in anaplastic carcinomas. Expression levels of thymosin beta-10 mRNA relative to thyroglobulin mRNA in anaplastic carcinomas were greatly increased compared with those in differentiated carcinomas.

Conclusion: These results suggest the usefulness of the quantitative measurement of thymosin beta-10 mRNA in molecular-based diagnosis of thyroid anaplastic carcinomas, but not of differentiated carcinomas.

+ For reprints and all correspondence: Toru Takano, Department of Laboratory Medicine, Osaka University Medical School, D2, 2–2, Yamadaoka, Suita, Osaka 565-0871, Japan. E-mail: ttakano@labo.med.osaka-u.ac.jp


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