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Japanese Journal of Clinical Oncology 32:363-364 (2002)
© 2002 Foundation for Promotion of Cancer Research

Randomized Controlled Trial to Evaluate Splenectomy in Total Gastrectomy for Proximal Gastric Carcinoma: Japan Clinical Oncology Group Study JCOG 0110-MF

Takeshi Sano1, Seiichiro Yamamoto2 and Mitsuru Sasako for the Gastric Cancer Surgical Study Group of Japan Clinical Oncology Group1,+,§

1 Gastric Surgery Division, National Cancer Center Hospital and 2 Cancer Information and Epidemiology Division, National Cancer Center Research Institute, Tokyo, Japan

A randomized controlled trial has started in Japan to evaluate the role of splenectomy in the surgical management of gastric cancer. Patients with T2 or deeper carcinoma in the proximal third of the stomach are intra-operatively randomized to either splenectomy or spleen preservation. Tumors invading the greater curvature of the stomach or those with apparent nodal involvement in the splenic hilum are excluded. Surgeons in 29 specialized institutions will recruit 500 patients. Endpoints are overall survival, operative morbidity, operative time and blood loss.

+ . T. Sano, study coordinator; S. Yamamoto, study statistician; M. Sasako, group chair.

§ For reprints and all correspondence: Takeshi Sano, Gastric Surgery Division, National Cancer Center Hospital. 5–1–1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan.


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