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Japanese Journal of Clinical Oncology 32:S10-S12 (2002)
© 2002 Foundation for Promotion of Cancer Research

The Strategy for Esophageal Cancer Control in High-risk Areas of China

Zhiwei Dong1, Pingzhang Tang2, Liandi Li3 and Guoqing Wang4,+

1Department of Epidemiology, Cancer Institute and Hospital (CI/H), Chinese Academy of Medical Sciences (CAMS), 2Department of Surgery of Head and Neck Cancers, CI/H, CAMS, 3Chinese National Office of Cancer Prevention and Treatment and 4Department of Endoscopy, CI/H, CAMS, Beijing, China

Even though the mortality from esophageal cancer has decreased during the last two decades nationwide in China, the mortality from esophageal cancer in high-risk areas is still at a high level. Moreover, the 5-year survival rate of patients with resectable esophageal cancer after treatment ranges between 20 and 30%, as majority of patients with esophageal cancer were diagnosed in late stages. Therefore, esophageal cancer control in high-risk areas in China remains a critical task. A strategy is proposed that the high-risk population would be screened by endoscopy with mucosal iodine staining and biopsy of all unstained lesions and diagnosis of severe dysplasia carcinoma in situ, and intra-mucosal carcinoma could be cured by radical mucosectomy. A pilot study showed that the strategy is feasible and cost-effective for the high prevalence of premalignant lesions and carcinomas in early stages. It would be expected that the mortality from esophageal cancer could be decreased in high-risk areas if the proposed strategy is carried out on a large scale.

+ For reprints and all correspondence: Zhiwei Dong, Department of Epidemiology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences, Panjiayuan 17, Chaoyang District, Beijing 100021, China


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