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Japanese Journal of Clinical Oncology 33:6-9 (2003)
© 2003 Foundation for Promotion of Cancer Research

Decreased Expression of Catalase mRNA in Thyroid Anaplastic Carcinoma

Yukiko Hasegawa1, Toru Takano1, Akira Miyauchi2, Fumio Matsuzuka2, Hiroshi Yoshida2, Kanji Kuma2 and Nobuyuki Amino1,+

1 Department of Laboratory Medicine, Osaka University Graduate School of Medicine, Suita, Osaka and 2 Kuma Hospital, Kobe, Japan

Background: A decreased expression of glutathione peroxidase mRNA, an antioxidant enzyme, was previously observed in thyroid anaplastic carcinomas.

Methods: To clarify the expression of antioxidant-related enzymes in thyroid anaplastic carcinomas, the expression levels of catalase, copper and zinc superoxide dismutase and manganese superoxide dismutase mRNA in 85 benign and malignant thyroid tissues were measured by means of real-time quantitative reverse transcription-polymerase chain reaction.

Results: Decreased expression levels of catalase and copper and zinc superoxide dismutase mRNAs, but not manganese mRNA, were observed in five anaplastic carcinomas compared with normal thyroid tissues and differentiated tumors.

Conclusion: These results suggest the possibility that anaplastic carcinoma cells are more likely to suffer damage by oxygen free radicals than normal thyroid cells or differentiated tumor cells.

+ For reprints and all correspondence: Toru Takano, Department of Laboratory Medicine, Osaka University Graduate School of Medicine, D2, 2–2, Yamadaoka, Suita, Osaka 565-0871, Japan.


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