Japanese Journal of Clinical Oncology 33:497-500 (2003)
© 2003 Foundation for Promotion of Cancer Research
Concurrent Chemoradiotherapy for Locoregionally Advanced Nasopharyngeal Carcinoma: is Intergroup Study 0099 Feasible in Japanese Patients?
Department of Radiology, Chiba University Hospital, Chiba, Japan
Background: Since the publication of the significant results of the Intergroup Study 0099 (IGS) in 1998, radical radiation therapy (RT) with concurrent and adjuvant chemotherapy has become the standard care for patients with locoregionally advanced nasopharyngeal carcinoma (NPC) in the United States. An update in 2001 further strengthened the findings of the interim analysis, however, no prospective randomized trials other than this study have confirmed the feasibility of this strategy.
Methods: We attempted to adopt the same combined modality treatment for three consecutive Japanese patients with locoregionally advanced NPC to evaluate its toxicity and efficacy. They were planned to receive radical RT concurrently with cisplatin every 3 weeks, and to receive adjuvant chemotherapy thereafter.
Results: The hematological toxicities were mild and well tolerated in all three patients; however, they all experienced severe (grade 3 and/or 4) skin reactions, pharyngitis and dysphagia, which led to the discontinuation of the planned chemotherapy. They were able to complete RT without treatment breaks, and all three patients achieved complete response at the end of treatment. However, two experienced recurrences after 8 and 10 months, respectively, and died of their disease.
Conclusions: Due to these severe acute adverse events, poor compliance and unsatisfactory outcomes, we have concluded that physicians should be careful in applying the concurrent chemoradiotherapy protocol employed by the IGS for locoregionally advanced Japanese NPC patients.
+ For reprints and all correspondence: Koichi Isobe, 1-8-1 Inohana, Chuo-ku, Chiba 260-8677, Japan. E-mail: isobeko{at}ho.chiba-u.ac.jp
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  Y. Nishimura, T. Shibata, K. Nakamatsu, S. Kanamori, R. Koike, M. Okubo, T. Nishikawa, I. Tachibana, M. Tamura, and M. Okumura A Two-step Intensity-modulated Radiation Therapy Method for Nasopharyngeal Cancer: The Kinki University Experience Jpn. J. Clin. Oncol., February 1, 2010; 40(2): 130 - 138. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Zenda, Y. Onozawa, M. Tahara, M. Kawashima, N. Shikama, S. Sasaki, and N. Boku Feasibility Study of Single Agent Cisplatin and Concurrent Radiotherapy in Japanese Patients with Squamous Cell Carcinoma of the Head and Neck: Preliminary Results Jpn. J. Clin. Oncol., October 8, 2007; (2007) hym106v1. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Demizu, R. Sasaki, T. Soejima, T. Maruta, Y. Okamoto, K. Yamada, E. Yoden, Y. Ejima, Y. Ota, H. Ishida, et al. Efficacy and Feasibility of Cisplatin-Based Concurrent Chemoradiotherapy for Nasopharyngeal Carcinoma Jpn. J. Clin. Oncol., October 1, 2006; 36(10): 620 - 625. [Abstract] [Full Text] [PDF]
|
|