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Japanese Journal of Clinical Oncology 33:538-540 (2003)
© 2003 Foundation for Promotion of Cancer Research

Successful Lithium Carbonate Treatment for Steroid-induced Depression Following Bone Marrow Transplantation: a Case Report

Mizuho Ito1, Masanari Onose2, Tomoki Yamada2, Hideki Onishi3, Shin Fujisawa4 and Heiwa Kanamori4,+

1 Department of Psychiatry, Kinko Hospital, Yokohama, 2 Department of Psychiatry, Yokohama City University School of Medicine, 3 Department of Psychiatry, Kanagawa Prefectural Cancer Center, Yokohama and 4 First Department of Internal Medicine, Yokohama City University School of Medicine, Yokohama, Japan

Drug-induced mental disturbances are frequent in bone marrow transplantation (BMT) patients who require numerous kinds of drugs. Although steroid-induced mental disorder is common in BMT settings, its treatment has not been fully investigated. We encountered a patient with acute myeloid leukemia who developed depressive disorder induced by steroid given for graft-versus-host disease treatment. Lithium carbonate was effective for the treatment of depressive disorder without causing side effects such as renal dysfunction. This study demonstrates the effectiveness of lithium carbonate for the treatment of depressive disorder induced by steroids in BMT settings.

+ For reprints and all correspondence: Mizuho Ito, Department of Psychiatry, Kinko Hospital, 2–5–1 Serigaya, Konan-ku, Yokohama 233-0006, Japan. E-mail: mizuho-i{at}kamakuranet.ne.jp


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