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Japanese Journal of Clinical Oncology 33:631-635 (2003)
© 2003 Foundation for Promotion of Cancer Research

Cyclooxygenase-2 Expression and its Relationship with Proliferation of Colorectal Adenomas

Takanobu Sato1, Keigo Yoshinaga3, Satoshi Okabe1, Takuya Okawa1, Tetsuro Higuchi1, Masayuki Enomoto1, Touichirou Takizawa2 and Kenichi Sugihara1,+

1 Digestive Surgery and 2 Surgical Pathology, Tokyo Medical and Dental University Graduate School, Tokyo and 3 Department of Surgery, Tokyo Hospital, National Printing Bureau, Tokyo, Japan

Background: Cyclooxygenase (COX)-2 may be linked to carcinogenesis. In the previous study, we examined COX-2 expression immunohistochemically in 95 adenomas and reported a significant correlation between its expression and the grade of dysplasia. To clarify the correlation between COX-2 expression and cell proliferation, we investigated Ki-67 labeling index using immunohistochemistry and its correlation with COX-2 expression.

Methods: Immunohistological staining for Ki-67 antigen was performed on 95 colorectal adenomas previously reported.

Results: The Ki-67 labeling index was significantly higher in the high-COX-2 group than in the low-COX-2 and negative groups in adenomas with moderate (44.5 ± 6.4% vs 33.0 ± 2.6%, 39.0 ± 6.2%; P = 0.01, P < 0.001, respectively) or severe dysplasia (47.2 ± 7.6% vs 40.3 ± 7.2%, 35.0 ± 5.4%; P = 0.02, P = 0.005, respectively). There was no correlation between Ki-67 labeling index and COX-2 expression in mild dysplasia.

Conclusions: These results suggest that COX-2 may play a causal role in cell proliferation in carcinogenesis.

+ For reprints and all correspondence: Takanobu Sato, Department of Surgery, Kyoundo Hospital, Sasaki Institute, 1–8 Kanda Surugadai, Chiyoda-ku, Tokyo 101-0062, Japan. E-mail: sato{at}po.kyoundo.jp


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