Japanese Journal of Clinical Oncology 33:73-77 (2003)
© 2003 Foundation for Promotion of Cancer Research
External Beam Radiation Monotherapy for Localized or Locally Advanced Prostate Cancer
1 Departments of Urology and 3 Radiology, Sapporo Medical University School of Medicine, Sapporo, 4 Department of Radiology, Hokkaido University School of Medicine, Sapporo, 2 Department of Urology, Sunagawa City Medical Center, Sunagawa, Hokkaido and 5 Department of Urology, Muroran City General Hospital, Muroran, Hokkaido, Japan
Purpose: We report the treatment results and complications of external beam radiation monotherapy for localized or locally advanced prostate cancer patients.
Methods: Fifty-four patients with T1b–3aN0(pN0)M0 prostate cancer were treated with external beam radiation monotherapy between 1989 and 2001 at four institutes.
Results: During the 4–122 month follow-up period (median: 25 months), 11 (20%) patients experienced biochemical failure, including one with simultaneous local recurrence. The 2-year actuarial biochemical control rate was 85%. Univariate analysis showed that the clinical T classification (P = 0.01), Gleason score (P = 0.006), pretreatment PSA (P = 0.02) and PSA nadir value (P = 0.01) were associated with a higher probability of biochemical failure. Multivariate analysis using the Cox proportional hazards model demonstrated that only the PSA nadir value was a strong predictor of PSA recurrence (P < 0.01). Adverse events were mild and tolerable. No severe urinary or bowel complications were observed.
Conclusions: External beam radiation monotherapy is effective for clinically organ-confined prostate cancer with a low incidence of severe complications in a mean follow-up period of 2 years.
+ For reprints and all correspondence: Atsushi Takahashi, Department of Urology, Sapporo Medical University School of Medicine, S-1, W-16, Chuo-ku, Sapporo 060-8543, Japan. E-mail: atakahas@sapmed.ac.jp
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