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Japanese Journal of Clinical Oncology 33:89-92 (2003)
© 2003 Foundation for Promotion of Cancer Research

A Case of Subglottic Carcinoma Effectively Treated with Intraluminal Irradiation Using Low Dose Rate Iridium-192 Thin Wires Combined with External Beam Irradiation

Masaki Wakisaka1, Nobukazu Fuwa2, Akira Matsumoto1, Hiroyuki Tachibana2, Takeshi Kodaira2, Kazuhisa Furutani2, Minoru Kamata2 and Hiromu Mori1,+

1 Department of Oncological Science (Department of Radiology), Division of Morphological Diagnosis and Less Invasive Therapy, Oita Medical University, Oita and 2 Department of Radiation Oncology, Aichi Cancer Center, Nagoya, Japan

Subglottic carcinoma is rare and has a poor prognosis. It is usually treated with surgical resection, external beam irradiation (EBR) and/or a combination of both. Intraluminal irradiation (IR) as a curative treatment for subglottic carcinoma has never been reported. We report a case of subglottic carcinoma in a 66-year-old man, who was effectively treated with IR combined with EBR. IR was conducted using low dose rate iridium-192 thin wires at a subglottic mucosal dose of 5.1–6.0 Gy per fraction, with a total dose of 43.8 Gy in eight fractions. EBR was administered, using cobalt-60 and 6 MV X-rays delivered at 2 Gy per fraction, with a total dose of 66 Gy in 33 fractions. Complete response was obtained without serious complications and no recurrence occurred in the 79-month follow-up period. IR combined with EBR is useful as a potential curative treatment. It should be considered as one of the treatment options for subglottic carcinoma.

+ For reprints and all correspondence: Masaki Wakisaka, Department of Oncological Science (Department of Radiology), Division of Morphological Diagnosis and Less Invasive Therapy, Oita Medical University, 1–1 Idaigaoka, Hasama-machi, Oita 879-5593, Japan. E-mail: wakisaka@oita-med.ac.jp


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