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Japanese Journal of Clinical Oncology 33:259-270 (2003)
© 2003 Foundation for Promotion of Cancer Research

Carcinogenesis and Its Modification by Environmental Endocrine Disruptors: In Vivo Experimental and Epidemiological Findings

Hiroyuki Tsuda1, Akihiro Naito1, Chuel Kyu Kim1, Katsumi Fukamachi1, Hiroshi Nomoto1 and Malcolm A. Moore1,2,+

1 Experimental Pathology and Chemotherapy Division, National Cancer Center Research Institute, Tokyo and 2 Asian Pacific Organization for Cancer Prevention Editorial Office, Tokyo, Japan

Although a great deal of concern has been raised about the hazard potential of endocrine disruptors present in the environment, the in vivo data available from both experimental and epidemiological studies suggest that the majority of those agents do not pose a risk with regard to cancer development. Indeed, naturally occurring examples such as isoflavonoids even appear to exert protective effects. Only for xenobiotics such as 1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane (DDT), polychlorinated biphenyls (PCBs) and tetrachloro-p-dioxin (TCDD) and special cases of phenols and phthalates is there unequivocal evidence of carcinogenicity and this appears to be directly linked to their toxicity. Thus, careful in vivo assessment is required before drawing any conclusions regarding agents capable of affecting the mammalian endocrine system.

+ For reprints and all correspondence: Hiroyuki Tsuda, Experimental Pathology and Chemotherapy Division, National Cancer Center Research Institute, 1–1 Tsukiji 5-chome, Chuo-ku, Tokyo 104-0045, Japan. E-mail: htsuda{at}gan2.ncc.go.jp


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