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Japanese Journal of Clinical Oncology 33:404-407 (2003)
© 2003 Foundation for Promotion of Cancer Research

Ovarian Metastasis Originating from Bronchioloalveolar Carcinoma: a Rare Presentation of Lung Cancer

Kun-Yun Yeh1, John W.-C. Chang1, Swei Hsueh2, Ting-Chang Chang3 and Meng-Chih Lin4,5,+

1 Division of Hemato-oncology, Department of Medicine, 2 Department of Pathology, 3 Department of Gynecology & Obstetrics, and 4 Division of Pulmonary & Critical Care Medicine, Department of Medicine, Chang Gung Memorial Hospital and 5 Department of Respiratory Care, Chang Gung University, Taipei, Taiwan

Ovarian metastasis originating from bronchioloalveolar carcinoma (BAC) has not been reported previously. We report a 63-year-old Chinese woman who was diagnosed as BAC with pleural metastasis in 1997. Four years later, she complained of vaginal bleeding, and a pelvic mass was discovered by an abdominal computerized tomography scan. Tumor debulking and total hysterectomy with bilateral salpingo-oopherectomy were performed. Pathology disclosed well-differentiated adenocarcinoma, with abundant clear cytoplasm, in the ovaries. Furthermore, immunohistochemical staining revealed that the tumor cells from the ovary and pleura were reactive to thyroid transcription factor 1 (TTF-1) and cytokeratin-7 (CK-7) but were negative for cytokeratin-20 (CK-20). The results of immunohistochemical staining, clinical course, and pathological features were compatible with the diagnosis of BAC with ovarian metastasis. In conclusion, to investigate the primary site of a metastatic ovarian cancer, clinicians should not forget the lungs since the incidence of lung cancer in females is increasing. Moreover, a monoclonal antibody panel for TTF-1, CK-7, and CK-20 may facilitate discrimination between primary and metastasized ovarian adenocarcinomas and/or identifying tumors of pulmonary origin.

+ For reprint and all correspondence: Meng-Chih Lin, Division of Pulmonary & Critical Care Medicine, Chang Gung Memorial Hospital and Department of Respiratory Care, Chang Gung University, 5 Fu-Shin Street, Kweishan, Taoyuan, Taiwan. E-mail: mengchih{at}adm.cgmh.org.tw


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