Japanese Journal of Clinical Oncology 33:470-476 (2003)
© 2003 Foundation for Promotion of Cancer Research
Influence of Clinical Parameters on Quality of Life During Chemotherapy in Patients with Advanced Non-small Cell Lung Cancer: Application of a General Linear Model
1 Department of Epidemiological and Clinical Research Information Management, Kyoto University Graduate School of Medicine, Kyoto, 2 Department of Pulmonary Medicine, Saitama Cancer Center, Saitama, 3 Division of Pulmonary Medicine, Tokai University School of Medicine, Kanagawa, 4 Department of Respiratory Disease, Musashigaoka Hospital, Kumamoto, 5 Division of Respiratory Medicine, Tokyo Metropolitan Komagome Hospital, Tokyo, 6 Department of Internal Medicine, Mitoyo General Hospital, Kagawa and 7 School of Health Sciences and Nursing, University of Tokyo, Tokyo, Japan
Objective: The aim of this study was to determine the relative influence of physician-assessed clinical parameters, including non-hematological adverse events and performance status, on quality of life (QOL) during chemotherapy.
Methods: QOL questionnaires consisting of four domains (functional, physical, mental and psychosocial) were self-administered every week during chemotherapy by patients with advanced non-small cell lung cancer in two phase III clinical trials; 377 patients who completed the questionnaires at baseline and at least once during the first course of therapy were analyzed. A general linear model was applied, where the four domains and the clinical parameters (nausea/vomiting, anorexia, diarrhea, fever, peripheral neuropathy and performance status) were used as the response and explanatory variables, respectively. In this model, the multi-dimensional and longitudinal aspects of QOL data were taken into account.
Results: All four domains were significantly affected by the occurrence of nausea/vomiting, anorexia and diarrhea. No influence of peripheral neuropathy on the domains was detected. Performance status was significantly related to the domains (except the psychosocial domain).
Conclusion: This study revealed, by examination of multi-dimensional repeated QOL data, that clinical parameters had significant effects on QOL in patients undergoing chemotherapy. Our findings suggest that supportive care to control non-hematological adverse events, especially gastrointestinal, could maintain overall QOL in cancer patients in an earlier phase of chemotherapy.
+ For reprints and all correspondence: Satoshi Morita, Department of Epidemiological and Clinical Research Information Management, Kyoto University Graduate School of Medicine, Yoshidakonoe-cho, Sakyo-ku, Kyoto 606-8501, Japan. E-mail: smorita{at}pbh.med.kyoto-u.ac.jp
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