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Japanese Journal of Clinical Oncology 2004 34(12):707-716; doi:10.1093/jjco/hyh139
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© 2004 Foundation for Promotion of Cancer Research

Review Article

Reduced-intensity Hematopoietic Stem Cell Transplantation (RIST) for Solid Malignancies

Masahiro Kami, Atsushi Makimoto, Yuji Heike and Yoichi Takaue

Department of Medical Oncology, Hematopoietic Stem Cell Transplantation Unit, The National Cancer Center Hospital, Tokyo, Japan

For reprints and all correspondence: Masahiro Kami, Department of Medical Oncology, Hematopoietic Stem Cell Transplantation Unit, the National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan. E-mail: mkami{at}ncc.go.jp

Received June 18, 2004; accepted October 6, 2004

Reduced intensity stem cell transplantation (RIST) is a new approach of stem cell transplantation, which has shown promising features as reported in multiple phase I and II studies. Elderly patients, who are not eligible for conventional myeloablative hematopoietic stem cell transplantation (HSCT), are now treatable with RIST. It has also reduced regimen-related toxicity and provided better prognosis in short-term follow-up than conventional HSCT. Among solid tumors, metastatic renal cell carcinoma was found to respond well to RIST. Clinical studies are currently being conducted to evaluate the efficacy of RIST in other types of solid tumors. However, the mechanism of graft-versus-host disease (GVHD) and graft-versus-tumor (GVT) effects remains unclear. More knowledge on the mechanism is crucial to enhance the antitumor effect and to improve the prognosis further.

Key Words: graft-versus-tumor effects • graft-versus-host disease • renal cell carcinoma • allogeneic hematopoietic stem cell transplantation • breast cancer


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