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Japanese Journal of Clinical Oncology 2004 34(12):755-758; doi:10.1093/jjco/hyh134
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© 2004 Foundation for Promotion of Cancer Research

Case Report

A Case of Bronchiolitis Obliterans Organizing Pneumonia Syndrome with Preceding Radiation Pneumonitis after Breast-conserving Therapy

Koichi Isobe1, Takashi Uno1, Hiroyuki Kawakami1, Naoyuki Ueno1, Hiroshi Yagata2, Natsuhiko Igarashi3 and Hisao Ito1

1 Department of Radiology, 2 First Department of Surgery and 3 Department of Respiratory Medicine, Chiba University Hospital, Chiba, Japan

For reprints and all correspondence: Koichi Isobe, Department of Radiology, Chiba University Hospital, 1-8-1 Inohana, Chuo-ku, Chiba, 260-8670, Japan. E-mail: isobeko{at}ho.chiba-u.ac.jp

Received June 24, 2004; accepted August 26, 2004

Recent case series have demonstrated that bronchiolitis obliterans organizing pneumonia (BOOP) after radiation therapy to the breast is a distinct clinicopathological entity. Most of the investigators speculated that radiation may prime the development of BOOP through an unidentified immunological process; however, none of them showed the relationship between direct radiation injury and BOOP. We report herein a case of a 67-year-old female with BOOP following direct radiation damage confined to the irradiated area after breast-conserving therapy. This is the first case demonstrating that BOOP after breast-conserving therapy arises from direct radiation injury.

Key Words: bronchiolitis obliterans organizing pneumonia • breast cancer • radiation therapy • radiation pneumonitis


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