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Japanese Journal of Clinical Oncology 34:269-273 (2004)
© 2004 Foundation for Promotion of Cancer Research

Erectile Function Following External Beam Radiotherapy for Clinically Organ-confined or Locally Advanced Prostate Cancer

Shin-ichi Hisasue1, Ryuichi Kato1, Atsushi Takahashi1, Naoya Masumori1, Naoki Itoh1, Noriomi Miyao1, Keiji Takatsuka2, Masahiro Yanase3, Atsushi Oouchi3, Masato Hareyama4 and Taiji Tsukamoto4,+

1 Department of Urology, Sapporo Medical University, Sapporo, 2 Department of Urology, Muroran City General Hospital, Muroran, Hokkaido, 3 Department of Urology, Sunagawa City Medical Center, Sunagawa, Hokkaido and 4 Department of Radiology, Sapporo Medical University, Sapporo, Japan

Background: External beam radiotherapy (XRT) has been a standard treatment for clinically localized prostate cancer. However, preservation of erectile function following XRT is controversial. In this study, the influence of XRT on erectile function of patients with clinically organ-confined or locally advanced prostate cancer was retrospectively evaluated.

Methods: The study included 34 of 84 patients with organ-confined or locally advanced prostate cancer who underwent XRT between 1995 and 2002. Erectile function following radiotherapy was assessed by a simple mailed questionnaire that was constructed for the study. To determine the predictive factors for erectile dysfunction following radiotherapy, data were analyzed by multivariate analysis with the Cox proportional hazards model.

Results: The modality of XRT was the only factor to independently predict erectile dysfunction following XRT. The maintenance rates of erectile function were 47.6% at 1 year and 19% at 3 years in patients who received the 3-dimensional conformal radiotherapy, which were significantly higher than in those who received conventional radiotherapy (P = 0.026).

Conclusions: XRT significantly reduced the maintenance rate of erectile function during the follow-up period, with the rate being 19% at 3 years in patients who received 3-dimensional conformal radiation. The XRT modality was involved in the reduction of erectile function. These results suggest that erectile dysfunction is a possible adverse event following XRT.

+ For reprints and all correspondence: Taiji Tsukamoto, Department of Urology, School of Medicine, Sapporo Medical University, S1W16, Chuo-ku, Sapporo 060-8543, Japan. E-mail: taijit{at}sapmed.ac.jp


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