© 2004 Foundation for Promotion of Cancer Research
Diagnosis of Peripheral Nerve Sheath Tumors around the Pelvis
1 Division of Orthopedic Surgery, Graduate School of Medical and Dental Sciences, Niigata University, 2 Department of Orthopedic Surgery, Niigata Cancer Center Hospital, 3 Department of Radiology, Niigata Citizen Hospital, 4 Section of Pathology, Niigata University Hospital, Niigata, Japan
Objective: To distinguish between benign and malignant peripheral nerve sheath tumors around the pelvis.
Methods: A retrospective study of 30 patients with benign and malignant peripheral nerve sheath tumors located around the pelvis was performed. Clinical, imaging and histological features of 19 benign and 11 malignant peripheral nerve sheath tumors around the pelvis were reviewed retrospectively.
Results: Nearly all patients exhibited pain at presentation in cases involving both benign and malignant tumors. Although tumor size, duration of symptoms and presence of sensory disturbance possessed little value in differential diagnosis, severe motor weakness was observed exclusively in patients presenting with malignant tumors. On CT or MRI, central enhancement was apparent in 11 of the19 benign tumors; in contrast, central enhancement was evident in one of the 11 malignant tumors. Fine needle aspiration cytology was performed in 11 tumors; correct diagnosis was achieved in four tumors. Core needle biopsy was performed in five tumors, all of which were correctly diagnosed with no neurological deficits. Immunohistochemically, all benign tumors were diffusely positive for S-100 protein, whereas malignant tumors were negative or focally positive for S-100 protein. Ki-67 index was less than 4% in all benign tumors; additionally, this index was 7–36% in malignant tumors.
Conclusion: Central enhancement pattern on imaging studies strongly suggests a benign tumor; in contrast, severe motor weakness suggests malignant lesions. Core needle biopsy was reliable with respect to preoperative diagnosis.
+ For reprints and all correspondence: Akira Ogose, Division of Orthopedic Surgery, Graduate School of Medical and Dental Sciences, Niigata University, Asahimachi 1–751, Niigata 951-8510, Japan. E-mail: aogose{at}med.niigata-u.ac.jp
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