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Japanese Journal of Clinical Oncology 2004 34(8):472-475; doi:10.1093/jjco/hyh075
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© 2004 Foundation for Promotion of Cancer Research

Case Report

Possible Therapeutic Role of Vitamin D3 in Aggressive Fibromatosis

Yildiz Ferah1, Kars Ayse2, Cengiz Mustafa1, Selek Ugur1, Gurkaynak Murat1 and Atahan I. Lale1

1 Department of Radiation Oncology and 2 Department of Medical Oncology, Hacettepe University Faculty of Medicine, 06100, Ankara, Turkey

For reprints and all correspondence: Yildiz Ferah, Hacettepe University Faculty of Medicine, Department of Radiation Oncology, 06100, Ankara, Turkey. E-mail: fyildiz{at}hacettepe.edu.tr

Received March 23, 2004; accepted May 15, 2004

Desmoids, also known as aggressive fibromatoses, are locally invasive tumors that are intermediate in their biological behavior that lies between benign fibrous proliferations and low-grade fibrosarcomas. In this report, we present a case of a young female patient with a huge tumoral mass located in the right shoulder region that recurred after total resection and was resistant to radio-chemo-hormonal therapy. Eventually, she responded to 1,25-(OH)2-vitamin D3 treatment.

Key Words: aggressive fibromatosis • vitamin D3


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