© 2004 Foundation for Promotion of Cancer Research
Case Report |
Aggressive Multimodal Treatment for Peritoneal Dissemination and Needle Tract Implantation of Hepatocellular Carcinoma: a Case Report*
1 Department of Surgery and Clinical Oncology, Osaka University, Graduate School of Medicine, Osaka and 2 Division of Hepatobiliary and Pancreatic Surgery, National Cancer Center Hospital East, Kashiwa, Chiba, Japan
For reprints and all correspondence: Hidenori Takahashi, Department of Surgery and Clinical Oncology, Osaka University, Graduate School of Medicine, 2–2, Yamadaoka, Suita, Osaka 565-0871, Japan. E-mail: h-takaha{at}dd.iij4u.or.jp
Received March 11, 2004; accepted June 16, 2004
We encountered a patient with hepatocellular carcinoma (HCC) with peritoneal dissemination and needle tract implantation, both of which were strongly suspected to have been caused by percutaneous needle biopsy. The patient was a 65-year-old man. Partial hepatectomy of subsegment VI had been performed following the diagnosis of HCC by percutaneous needle biopsy in February 1997. After this first surgery, the patient additionally underwent five further surgeries for the treatment of intrahepatic recurrences, peritoneal recurrences and needle tract implantation caused by the percutaneous needle biopsy. The intrahepatic and peritoneal recurrences were surgically controlled for 3 years after the fifth operation. The needle tract implantation was first resected in February 2001. Since then, treatment by surgery and radiotherapy has been administered twice for local recurrences forming tumor thrombosis of the abdominal wall. Now, 7 years after the first surgery, the patient remains alive without any evidence of recurrence. This case report serves to emphasize that needle tract implantation and peritoneal seeding caused by percutaneous needle biopsy are rare but possible complications. When such iatrogenic spreading of malignant cells occurs, aggressive multimodal treatment is well worth considering. Wide resection of the tumor including the adjacent soft tissues should be performed in these cases, considering that the tumor spreads along the subcutaneous veins in needle tract implantation of HCC and repeated aggressive surgeries could provide good local control.
Key Words: hepatocellular carcinoma • percutaneous needle biopsy • peritoneal recurrence • needle tract implantation
* This paper was presented at the 5th World Congress of the International Hepato-Pancreato-Biliary Association, Tokyo, April 25–29, 2002.
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