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Japanese Journal of Clinical Oncology 2005 35(1):40-44; doi:10.1093/jjco/hyi001
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© 2005 Foundation for Promotion of Cancer Research

Case Report

Concurrent Proton Beam Radiotherapy and Systemic Chemotherapy for the Metastatic Liver Tumor of Gastric Carcinoma: a Case Report

Takeshi Gohongi1, Koichi Tokuuye2, Hiroyuki Iida1, Reiko Nakai1, Naoto Gunji1, Yasuyuki Akine2 and Kazuo Orii1

1 Department of Surgery, Tsukuba-Gakuen Hospital, Tsukuba, Ibaraki and 2 Department of Radiation Oncology, Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Japan

For reprints and all correspondence: Takeshi Gohongi, Department of Surgery, Tsukuba-Gakuen Hospital, Tsukuba, Ibaraki 305-0857, Japan. E-mail: t-gohongi{at}gakuen-hospital.or.jp

Received June 12, 2004; accepted August 30, 2004

We report a case of a woman with a metastatic liver tumor from gastric carcinoma, who has been successfully treated with concurrent proton beam therapy and systemic chemotherapy. A 76-year-old woman underwent distal gastrectomy with regional lymph node dissection for advanced gastric carcinoma on January 17, 2002. She received five courses of sequential chemotherapy with methotrexate–5-fluorouracil after the surgical resection. A metastatic liver tumor was detected in the caudate lobe of the liver by computed tomography at 6 months after the surgical resection. We employed concurrent proton beam therapy and systemic chemotherapy which consisted of 5-fluorouracil (250 mg/body per day, as a 24-h intravenous injection for 4 weeks) and low dose cisplatin (10 mg/body on days 1–5 every week for 4 weeks). Proton beam therapy targeting the metastatic liver tumor was performed in a daily fraction of 3 Gy, 5 days per week, with a total dose of 66 Gy over 30 days. The tumor disappeared 3 months after the treatment and no recurrence has been observed for 2 years after termination of the treatment. Throughout the entire course of treatment, the patient received injections of granulocyte stimulating factor subcutaneously for grade 3 leukopenia. She never complained of abdominal symptoms, such as epigastralgia, nausea or diarrhea. Liver failure related to proton irradiation has not been observed. This concurrent proton beam radiotherapy with systemic chemotherapy could be an effective treatment modality for metastatic liver tumor from gastric carcinoma.

Key Words: chemoradiotherapy • 5-fluorouracil • gastric carcinoma • metastatic liver tumor • proton


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