Japanese Journal of Clinical Oncology Advance Access originally published online on September 19, 2005
Japanese Journal of Clinical Oncology 2005 35(10):587-590; doi:10.1093/jjco/hyi152
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© 2005 Foundation for Promotion of Cancer Research
Distribution of the Deepest Penetrating Point of Minute Submucosal Gastric Cancer
1 Endoscopy Division, 2 Department of Surgical Oncology and 3 Department of Clinical Laboratory, National Cancer Center Hospital, Tokyo, Japan
For reprints and all correspondence: Takuji Gotoda, Endoscopy Division, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan. E-mail: tgotoda{at}ncc.go.jp
Received April 21, 2005; accepted August 10, 2005
Background: Accurate assessment of depth of invasion is critical in decision-making for additional surgery after endoscopic resection of early gastric cancer (EGC). Although this depth of invasion is determined at the deepest point of submucosal invasion (DPSI), there is no literature describing the distribution of deepest invasion point.
Objective: To describe the location of the DPSI, and to determine whether it is possible to predict this point by clinicopathological features before treatment.
Methods: One hundred and ninety-five lesions of EGC with minute submucosal invasion, which had been resected en bloc between 1991 and 2003, were reviewed. For each lesion, we recorded the location of the DPSI as being in one of three areas demarcated by three concentric equal distance rings. We also examined the correlation between the location of the deepest penetration and the clinicopathological characteristics.
Results: The DPSI was located most often (53%) in the central, less often (31%) in the middle and least often (16%) in the outermost area. There was no significant correlation between the distribution of the deepest point and any clinicopathological features.
Conclusions: The DPSI was not always in the central area, and it was impossible to predict its location by clinicopathological features alone. To obtain an accurate measure of depth of tumor invasion, we must histologically assess the entire lesion by thin sections.
Key Words: minute submucosal penetration • early gastric cancer • depth of invasion • endoscopic mucosal resection