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Japanese Journal of Clinical Oncology 2005 35(2):94-96; doi:10.1093/jjco/hyi027
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© 2005 Foundation for Promotion of Cancer Research

Case Report

Acute Pancreatitis During All-trans-retinoic Acid Treatment for Acute Promyelocytic Leukemia in a Patient Without Overt Hypertriglyceridemia

Hao-Wei Teng1,2, Li-Yuan Bai1,2, Ta-Chung Chao1,2, Wei-Shu Wang1,2 and Po-Min Chen1,2

1 Division of Medical Oncology, Department of Medicine, Taipei Veterans General Hospital and 2 School of Medicine, National Yang-Ming University Taipei, Taiwan

For reprints and all correspondence: Po-Min Chen, Division of Medical Oncology, Department of Medicine, Taipei Veterans General Hospital, 201, Sec 2, Shih-Pai Road, Taipei 112, Taiwan. E-mail: pmchen{at}vghtpe.gov.tw

Received August 6, 2004; accepted September 29, 2004

All-trans-retinoic acid (ATRA) has been successfully used in the treatment of acute promyelocytic leukemia (APL). One of its adverse effects is acute pancreatitis. In the literature, a proposed cause of acute pancreatitis is hypertriglyceridemia. Here, we present the case of a 45-year-old male with APL, treated with ATRA combined with induction chemotherapy (cytarabine and idarubicin), who developed acute pancreatitis without overt hypertriglyceridemia. This finding suggests that hypertriglyceridemia might not be the sole contributing factor in the pathogenesis of ATRA-induced acute pancreatitis and that attention should be paid to the possibility that ATRA treatment causes acute pancreatitis in the absence of overt hypertriglyceridemia.

Key Words: acute promyelocytic leukemia • acute pancreatitis • all-trans-retinoic acid • hypertriglyceridemia


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