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Japanese Journal of Clinical Oncology Advance Access originally published online on May 10, 2005
Japanese Journal of Clinical Oncology 2005 35(5):251-255; doi:10.1093/jjco/hyi077
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© 2005 Foundation for Promotion of Cancer Research

Phase II Study of Paclitaxel and Carboplatin in Advanced Gastric Cancer Previously Treated with 5-Fluorouracil and Platinum

Heung Moon Chang1, Tae Won Kim1, Baek-Yeol Ryu2, Seong-Jun Choi2, Yeon Hee Park2, Jung Shin Lee1, Woo Kun Kim1 and Yoon-Koo Kang1

1 Division of Oncology, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine and 2 Department of Internal Medicine, Korea Cancer Center Hospital, Korea Institute of Radiological and Medical Sciences, Seoul, Korea

For reprints and all correspondence: Heung Moon Chang, Division of Oncology, Department of Internal Medicine, Asan Medical Center, 388-1 Pungnap-dong, Songpa-gu, Seoul 138-736, Korea. E-mail: changhm{at}amc.seoul.kr

Received March 31, 2005; accepted April 1, 2005

Background: The combination of paclitaxel and carboplatin has been used to treat patients with many types of tumor, including gastric cancer. We evaluated the efficacy and safety of this combination in advanced gastric cancer patients previously treated with 5-fluorouracil and platinum.

Methods: Patients who had pathologically been proven to have measurable lesions were treated with paclitaxel (200 mg/m2 for 3 h) and carboplatin [area under the concentration–time curve (AUC = 6)] on day 1 and in 21 day cycles.

Results: A partial response was achieved in 10 of 45 patients [22%, 95% confidence interval (CI), 10–34]. Of the 32 patients previously treated with cisplatin, four (13%) achieved partial response, whereas, of the 13 patients previously treated with heptaplatin, six (46%) achieved partial response. In all patients, the median time to progression was 14 weeks (95% CI, 10–18), and the median overall survival was 32 weeks (95% CI, 26–38). The most common grade 3/4 adverse events were neutropenia (40% of patients) and neuropathy (2.2%). Two patients developed neutropenic fever. However, there were no treatment-related deaths.

Conclusions: Combination chemotherapy with paclitaxel and carboplatin is feasible in patients with advanced gastric cancer who were previously treated with 5-fluorouracil and platinum.

Key Words: gastric cancer • carboplatin • paclitaxel


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 Jpn J Clin OncolHome page
Y. H. Kim, K. Yamaguchi, Y.-J. Bang, H. Takiuchi, W. K. Kang, A. Sato, Y.-K. Kang, J. Sakamoto, C. Abe, and Y. Sakata
Phase II Study of Biweekly Paclitaxel and Cisplatin Combination Chemotherapy in Advanced Gastric Cancer: Korea Japan Collaborative Study Group Trial
Jpn. J. Clin. Oncol., August 2, 2007; (2007) hym054v1.
[Abstract] [Full Text] [PDF]


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