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Japanese Journal of Clinical Oncology Advance Access originally published online on June 3, 2005
Japanese Journal of Clinical Oncology 2005 35(6):342-348; doi:10.1093/jjco/hyi094
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© 2005 Foundation for Promotion of Cancer Research

Expression of E-Cadherin and uPA and their Association with the Prognosis of Pancreatic Cancer

Sang Joon Shin1, Kyeong Ok Kim1, Min Kyoung Kim1, Kyung Hee Lee1, Myung Soo Hyun1, Keuk Jun Kim2, Joon Hyuk Choi2 and Hong Seok Song3

1 Division of Oncology-Hematology, Department of Medicine, 2 Department of Pathology, Yeungnam University College of Medicine and 3 Keimyung University, Daegu, Korea

For reprints and all correspondence: Kyung Hee Lee, Division of Oncology-Hematology, Department of Internal Medicine, College of Medicine, Yeungnam University, Daemyeung-Dong, 317-1, Namg-Gu, Daegu 705-717, South Korea. E-mail: lkhee{at}med.yu.ac.kr

Received February 10, 2005; accepted April 27, 2005

Objective: E-cadherin (ECD) and urokinase plasminogen activator (uPA) have been noted as markers for tumor metastasis and prognosis in several tumors. We thus investigated the relationship between the expression of ECD and uPA and the clinicopathological characteristics in pancreatic cancer.

Methods: The expression of ECD and uPA was evaluated in pancreatic cancer tissues from 53 patients.

Results: Among 53 tumor tissues, those from 29 (54.7%) patients showed positive ECD expression and those from 22 (41.5%) patients showed positive expression of uPA. There were four subgroups of ECD/uPA expression: ECD-positive/uPA-negative, ECD-negative/uPA-negative, ECD-positive/uPA-positive and ECD-negative/uPA-positive. These patterns were found in 14 (26.4%), 11 (20.8%), nine (17%) and 19 (35.8%) patients, respectively. The tumor tissues with ECD-negative and uPA-positive expression were associated with larger tumor, distant metastasis and an increased clinical stage. There was a difference in the median survival time between the patients with ECD-positive/uPA-negative pancreatic tissues (median: 18.7 months) and the patients with ECD-negative/uPA-positive pancreatic tissues (median: 7.5 months, P < 0.05), and there was a statistically significant difference in survival curves between these two groups.

Conclusion: The combined analysis concerning uPA and E-cadherin expression may be a useful predictor of metastasis in pancreactic cancer.

Key Words: pancreatic neoplasms • E-cadherins • urokinase plasminogen activator


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Related articles in JJCO:

Expression of E-Cadherin and uPA and their Association with the Prognosis of Pancreatic Cancer
Sang Joon Shin, Kyeong Ok Kim, Min Kyoung Kim, Kyung Hee Lee, Myung Soo Hyun, Keuk Jun Kim, Joon Hyuk Choi, and Hong Seok Song
JJCO 2005 35: 487. [Extract] [FREE Full Text]  



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