Japanese Journal of Clinical Oncology Advance Access originally published online on June 23, 2005
Japanese Journal of Clinical Oncology 2005 35(7):417-419; doi:10.1093/jjco/hyi106
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
© 2005 Foundation for Promotion of Cancer Research
Case Report |
Successful Treatment of Pulmonary Artery Sarcoma by a Two-drug Combination Chemotherapy Consisting of Ifosfamide and Epirubicin
1 Department of Hematology, Oncology and Respiratory Medicine, 2 Department of Thoracic Surgery and 3 Department of Pathology, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan
For reprints and all correspondence: Akiko Uchida, Department of Hematology, Oncology and Respiratory Medicine Okayama University Graduate School of Medicine and Dentistry, 2-5-1 Shikata-cho, Okayama 700-8558, Japan. E-mail: NQC26450{at}nifty.com
Received July 19, 2004; accepted March 8, 2005
We describe a case of 63-year-old woman with pulmonary artery sarcoma successfully treated with chemotherapy. She developed acute shortness of breath, and left chest and shoulder pain. Although a diagnosis of acute pulmonary embolism was made at a local hospital and she received anticoagulation and thrombolysis therapy, no improvement was achieved. Thereafter, she underwent a pulmonary thromboectomy in our hospital, and the histological diagnosis was intimal sarcoma of the pulmonary artery. Since post-operative computed tomography (CT) scans of the chest showed obvious persistence of an intraluminal hypoattenuated area in the left main pulmonary artery, the patient was treated with four cycles of a doublet chemotherapy consisting of ifosfamide (2.5 g/m2/day) on days 1–5 and epirubicin (45 mg/m2/day) on days 2 and 3. CT scans of the chest after four cycles showed marked regression of the intraluminal hypoattenuated area in the left main pulmonary artery. This is the first case of pulmonary artery sarcoma responding to chemotherapy. Surgical resection is currently the most hopeful treatment for pulmonary artery sarcoma. However, intensive chemotherapy is worth trying in unresectable patients.
Key Words: intimal sarcoma • chemotherapy • pulmonary artery
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  S. H. Blackmon, D. C. Rice, A. M. Correa, R. Mehran, J. B. Putnam, W. R. Smythe, J.-C. Walkes, G. L. Walsh, C. Moran, H. Singh, et al. Management of Primary Pulmonary Artery Sarcomas. Ann. Thorac. Surg., March 1, 2009; 87(3): 977 - 984. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Nakahira, H. Ogino, H. Sasaki, and N. Katakami Long-term survival of a pulmonary artery sarcoma produced by aggressive surgical resection and adjuvant chemoradiotherapy Eur. J. Cardiothorac. Surg., August 1, 2007; 32(2): 388 - 390. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. A. Pewarchuk, C. L. Nassaralla, and D. E. Midthun A 39-Year-Old Woman With Cough, Chest Pressure, and Worsening Dyspnea Chest, March 1, 2007; 131(3): 934 - 937. [Full Text] [PDF]
|
|
|
|
|
|
A. Maruo, Y. Okita, K. Okada, T. Yamashita, S. Tobe, and N. Tanimura Surgical Experience for the Pulmonary Artery Sarcoma Ann. Thorac. Surg., December 1, 2006; 82(6): 2014 - 2016. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Singh, C. LaFalce, G. Marrone, D. Shade, and N. Singh Recurrent dyspnea on exertion in a 71-year-old man with prior pulmonary embolism. Chest, October 1, 2006; 130(4): 1244 - 1247. [Full Text] [PDF]
|
|