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Japanese Journal of Clinical Oncology Advance Access originally published online on January 25, 2006
Japanese Journal of Clinical Oncology 2006 36(1):60-63; doi:10.1093/jjco/hyi219
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© 2006 Foundation for Promotion of Cancer Research

Case Report

Neutropenic Colitis during Standard Dose Combination Chemotherapy with Nedaplatin and Irinotecan for Testicular Cancer

Ei-Ichiro Takaoka, Koji Kawai, Satoshi Ando, Toru Shimazui and Hideyuki Akaza

Department of Urology, Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan

For reprints and all correspondence: Ei-ichiro Takaoka, 2-12-16-1306 Minato, Chuo-ku, Tokyo 104-0043, Japan. E-mail: tach-tech-voice{at}mvb.biglobe.ne.jp

Received July 31, 2005; accepted November 7, 2005

A 54-year-old man received combination chemotherapy with nedaplatin and irinotecan as salvage chemotherapy for refractory non-seminomatous testicular cancer. The patient developed abdominal pain and high fever on Day 21 after the initiation of chemotherapy. Computed tomography revealed thickening of the terminal ileum wall and paralytic ileus. The patient recovered with intensive supportive management including broad-spectrum antibiotics, bowel rest with gastric intubation and intravenous {gamma}-globulin. Neutropenic colitis has been thought to be a serious gastrointestinal complication associated with chemotherapy for hematological malignancy. The mortality rate is as high as 21–48% according to a recent review. The present case indicates that the neutropenic colitis can occur under neutropenic conditions induced by the standard-dose chemotherapy for solid cancer.

Key Words: solid cancer • chemotherapy • neutropenic colitis text


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