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Japanese Journal of Clinical Oncology 2006 36(2):109-112; doi:10.1093/jjco/hyi241
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© 2006 Foundation for Promotion of Cancer Research

Case Reports

Small-Cell Carcinoma of the Esophagus Associated with a Paraneoplastic Neurological Syndrome: A Case Report Documenting a Complete Response

Takuya Shimoda, Wasaburou Koizumi, Satoshi Tanabe, Katuhiko Higuchi, Tohru Sasaki, Norisuke Nakayama, Mizutomo Azuma, Katsunori Saigenji, Tomoya Katou and Mieko Ogino

Department of Internal Medicine, Kitasato University East Hospital, Sagamihara, Kanagawa, Japan

For reprints and all correspondence: Takuya Shimoda, Department of Internal Medicine, Kitasato University School of Medcine, 1-15-1, Kitasato, Sagamihara, Kanagawa, 228-8555, Japan. E-mail: ep-doc{at}kitasato-u.ac.jp

Received August 30, 2005; accepted November 29, 2005

We describe a case of small-cell carcinoma of the esophagus associated with a paraneoplastic neurological syndrome. Sensorimotor neuropathy had developed 3 years earlier, and neurological symptoms had slowly worsened. Small-cell carcinoma of the esophagus was incidentally diagnosed while investigating the cause of the neurological symptoms. A paraneoplastic neurological syndrome was diagnosed on the basis of cancer and exclusion of other known causes of neurological symptoms. The patient was given combination chemoradiotherapy. There was a complete response to three courses of chemoradiotherapy, with no evidence of disease recurrence 6 years after the diagnosis. There was no progression of paraneoplastic neurological symptoms after the complete response.

Key Words: small-cell carcinoma of the esophagus • paraneoplastic neurologic syndrome • chemotherapy • radiation therapy


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