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Japanese Journal of Clinical Oncology Advance Access originally published online on May 30, 2006
Japanese Journal of Clinical Oncology 2006 36(5):263-268; doi:10.1093/jjco/hyl024
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© 2006 Foundation for Promotion of Cancer Research

Association between Cyclooxygenase-2 and Matrix Metalloproteinase-2 Expression in Non-Small Cell Lung Cancer

Jae Ho Byun, Myung Ah Lee, Sang Young Roh, Byoung Yong Shim, Sook Hee Hong, Yoon Ho Ko, Su Jin Ko, In Sook Woo, Jin Hyoung Kang, Young Seon Hong, Kyung Shik Lee, Ah Won Lee1, Gyeong Sin Park1 and Kyo Yeong Lee1

Departments of Internal Medicine and 1 Clinical Pathology, College of Medicine, The Catholic University of Korea, Seoul, South Korea

For reprints and all correspondence: Myung Ah Lee, Division of Oncology, Department of Internal Medicine, College of Medicine, Catholic University, Kangnam St Mary's Hospital #505 Banpo-dong, Seocho-gu, Seoul 137–040, South Korea. E-mail: angelamd{at}catholic.ac.kr

Received October 12, 2005; accepted February 8, 2006

Background: Cyclooxygenase-2 (COX-2) contributes to invasiveness of cancer through activation of several matrix metalloproteinases (MMPs). Matrix metalloproteinase-2 (MMP-2) is a proteolytic enzyme that degrades the extracellular matrix, and has been linked to invasion and metastasis. This study aims to assess the correlation of the COX-2 expression and the MMP-2 expression in patients with non-small cell lung cancer (NSCLC).

Methods: We analyzed the protein expressions of COX-2 and MMP-2 by immunohistochemical staining on the tissue array specimens from 204 patients with completely resected NSCLC. A <10% immunostaining of the cancer cells was considered negative, while >10% was considered positive.

Results: The COX-2 expression was positive in 68.1% and that of the MMP-2 was positive in 45.6%. The positive expression rate of MMP-2 (52.5%) in the positive COX-2 group was higher than that in the negative COX-2 group (30.8%, P = 0.004). Furthermore, the MMP-2 expression was associated with lymph node involvement, the tumor stage and the histological type. The patients with a positive MMP-2 expression showed a reduced survival (P = 0.048).

Conclusions: The COX-2 expression is associated with the MMP-2 expression in NSCLC patients: the latter may also be associated with tumor progression and reduced survival in NSCLC patients.

Key Words: cyclooxygenase-2 • matrix metalloproteinase-2 • non-small cell lung cancer


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