Association between Cyclooxygenase-2 and Matrix Metalloproteinase-2 Expression in Non-Small Cell Lung Cancer

doi:10.1093/jjco/hyl024

Japanese Journal of Clinical Oncology Advance Access originally published online on May 30, 2006
Japanese Journal of Clinical Oncology 2006 36(5):263-268; doi:10.1093/jjco/hyl024

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Association between Cyclooxygenase-2 and Matrix Metalloproteinase-2 Expression in Non-Small Cell Lung Cancer

Jae Ho Byun, Myung Ah Lee, Sang Young Roh, Byoung Yong Shim, Sook Hee Hong, Yoon Ho Ko, Su Jin Ko, In Sook Woo, Jin Hyoung Kang, Young Seon Hong, Kyung Shik Lee, Ah Won Lee¹, Gyeong Sin Park¹ and Kyo Yeong Lee¹

Departments of Internal Medicine and ¹ Clinical Pathology, College of Medicine, The Catholic University of Korea, Seoul, South Korea

For reprints and all correspondence: Myung Ah Lee, Division of Oncology, Department of Internal Medicine, College of Medicine, Catholic University, Kangnam St Mary's Hospital #505 Banpo-dong, Seocho-gu, Seoul 137–040, South Korea. E-mail: angelamd{at}catholic.ac.kr

Received October 12, 2005; accepted February 8, 2006

Background: Cyclooxygenase-2 (COX-2) contributes to invasivenessof cancer through activation of several matrix metalloproteinases(MMPs). Matrix metalloproteinase-2 (MMP-2) is a proteolyticenzyme that degrades the extracellular matrix, and has beenlinked to invasion and metastasis. This study aims to assessthe correlation of the COX-2 expression and the MMP-2 expressionin patients with non-small cell lung cancer (NSCLC).

Methods: We analyzed the protein expressions of COX-2 and MMP-2by immunohistochemical staining on the tissue array specimensfrom 204 patients with completely resected NSCLC. A <10%immunostaining of the cancer cells was considered negative,while >10% was considered positive.

Results: The COX-2 expression was positive in 68.1% and thatof the MMP-2 was positive in 45.6%. The positive expressionrate of MMP-2 (52.5%) in the positive COX-2 group was higherthan that in the negative COX-2 group (30.8%, P = 0.004). Furthermore,the MMP-2 expression was associated with lymph node involvement,the tumor stage and the histological type. The patients witha positive MMP-2 expression showed a reduced survival (P = 0.048).

Conclusions: The COX-2 expression is associated with the MMP-2expression in NSCLC patients: the latter may also be associatedwith tumor progression and reduced survival in NSCLC patients.

Key Words: cyclooxygenase-2 • matrix metalloproteinase-2 • non-small cell lung cancer

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