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Japanese Journal of Clinical Oncology Advance Access originally published online on May 30, 2006
Japanese Journal of Clinical Oncology 2006 36(5):290-294; doi:10.1093/jjco/hyl030
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© 2006 Foundation for Promotion of Cancer Research

Monotherapy with Carbon Ion Radiation for Localized Prostate Cancer

Jun Shimazaki1, Koichiro Akakura1, Hiroyoshi Suzuki1, Tomohiko Ichikawa1, Hiroshi Tsuji2, Hitoshi Ishikawa2, Masaoki Harada3 and Hirohiko Tsujii2

1 Department of Urology, Graduate School of Medicine, Chiba University, 2 Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, Chiba 3 Department of Surgical Pathology, Kanagawa Cancer Center, Yokohama, Japan

For reprints and all correspondence: Jun Shimazaki, Department of Urology, Graduate School of Medicine, Chiba University, Chuo-ku, Chiba-shi 260-8670, Japan. E-mail: shimajun{at}opal.famille.ne.jp

Received December 24, 2005; accepted February 13, 2006

Background: Radiation treatment for localized prostate cancer has become a prominent choice of monotherapy, and carbon ion beam is a powerful means for this purpose.

Methods: In total, 37 patients with localized prostate cancer were treated by monotherapy with carbon ion radiation and the outcome, more than 4 years later, was followed.

Results: PSA relapse-free survival was overall 85%, 5 years after radiation, and 96% in low-risk patients. Local control was mostly achieved, and no cancer-specific death was obtained. Except in cases of relapse, 1.0 ng/ml or less of PSA was shown in 78%, 3 years after radiation. Half of biopsy specimens out of 12 cases revealed non-viable or no cancer cells after a rather short time from treatment.

Conclusion: Monotherapy with carbon ion radiation may be an excellent treatment for localized prostate cancer with low risk.

Key Words: prostate cancer • localized stage • radiotherapy • carbon ion radiation


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