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Japanese Journal of Clinical Oncology 2007 37(12):955-960; doi:10.1093/jjco/hym125
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© The Author (2008). Published by Oxford University Press. All rights reserved

Prognostic Implications of Glucose Transporter Protein-1 (Glut-1) Overexpression in Bone and Soft-Tissue Sarcomas

Makoto Endo1, Ukihide Tateishi2,, Kunihiko Seki3, Umio Yamaguchi1, Fumihiko Nakatani1, Akira Kawai1, Hirokazu Chuman1 and Yasuo Beppu1

1 Division of Orthopaedic Oncology, National Cancer Center Hospital, Tokyo
2 Division of Diagnostic Radiology, National Cancer Center Hospital, Tokyo, Japan
3 Division of Clinical Laboratory, National Cancer Center Hospital, Tokyo, Japan

For reprints and all correspondence: Ukihide Tateishi, Division of Diagnostic Radiology, National Cancer Center Hospital, 5-1-1, Tsukiji, Chuo-ku, 104-0045, Tokyo, Japan. E-mail: utateish{at}ncc.go.jp

Received June 28, 2007; accepted August 13, 2007

Background: The glucose transporter protein 1 (Glut-1) overexpression is associated with poor overall survival (OS) in various malignant tumors. The aim of this study was to investigate prognostic significance of Glut-1 overexpression in patients with bone and soft-tissue sarcomas.

Methods: A total of 67 patients (mean age, 43 years; range, 8–79 years) with bone and soft tissue sarcomas were analyzed. Pathologic confirmation was observed from surgical specimens in all patients. Pathologic variables including tumor differentiation, necrosis, mitotic index, MIB-1 (Ki-67) grade and Glut-1 expression were assessed. Clinical characteristics and pathologic variables were determined by Kaplan–Meyer curve of OS after treatment.

Results: Glut-1 overexpression was found in 56 patients (83%). The patients with Glut-1 overexpression showed significantly poor OS compared with those without Glut-1 overexpression (P = 0.029). The presence of metastasis, treatment without surgical resection, tumor differentiation, necrosis, mitotic index and MIB-1 grade were also significantly negative prognostic factors. The presence of metastasis was independently associated with poor OS (P = 0.031).

Conclusions: Assessment of Glut-1 expression prior to treatment has a predictive potential effect in patients with bone and soft-tissue sarcomas.

Key Words: sarcoma • glucose trasnsporter protein • prognosis


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