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Japanese Journal of Clinical Oncology 2007 37(2):146-149; doi:10.1093/jjco/hyl147
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© 2007 Foundation for Promotion of Cancer Research

Three Cases of Multiple Thymoma with a Review of the Literature

Takeshi Mori, Hiroaki Nomori, Koei Ikeda, Masakazu Yoshioka, Hironori Kobayashi, Kazunori Iwatani, Kentaro Yoshimoto and Ken-Ichi Iyama

Department of Thoracic Surgery and Department of Surgical Pathology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan

For reprints and all correspondence: Hiroaki Nomori, Department of Thoracic Surgery, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Kumamoto 860-8556, Japan. E-mail: hnomori{at}qk9.so-net.ne.jp

Received June 17, 2006; accepted July 27, 2006

Three cases of patients with synchronous multiple thymoma are reported. Two patients had two thymomas each and the remaining patient had three. The thymomas in each patient all displayed similar histological findings, of which the WHO histological classification were type B2, A and B1, respectively. With a modified Masaoka staging system, the thymomas were determined to be stages II-1 and I in patient 1, one of stage III and two of stage I in patient 2, and two of stage II-1 in patient 3. We reviewed nine reported cases of multiple thymoma in which histological findings were provided and discuss whether they developed from multi-centric origin or from intra-thymic metastasis.

Key Words: thymoma • multiple developments • multi-centric development • recurrence


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