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Japanese Journal of Clinical Oncology Advance Access originally published online on June 19, 2007
Japanese Journal of Clinical Oncology 2007 37(5):376-381; doi:10.1093/jjco/hym039
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© 2007 Foundation for Promotion of Cancer Research

First Attempt of Boron Neutron Capture Therapy (BNCT) for Hepatocellular Carcinoma

Minoru Suzuki1,, Yoshinori Sakurai2, Satoru Hagiwara3, Shinichiro Masunaga1, Yuko Kinashi1, Kenji Nagata1, Akira Maruhashi2, Masatoshi Kudo3 and Koji Ono1

1 Particle Oncology Research Center
2 Division of Medical Physics, Research Reactor Institute, Kyoto University, 2-1010, Asashiro-nishi, Kumatori-cho, Sennan-gun, Osaka
3 Department of Gastroenterology and Hepatology, Kinki University, School of Medicine, 377-2 Ohno-Higashi, Osaka-Sayama, Osaka, Japan

For reprints and all correspondence: Minoru Suzuki, Particle Oncology Research Center, Research Reactor Institute, Kyoto University, 2-1010, Asashiro-nishi, Kumatori-cho, Sennan-gun, Osaka 590-0494, Japan. E-mail: msuzuki{at}rri.kyoto-u.ac.jp

Received October 18, 2006; accepted December 18, 2006

A 60-year-old man with multiple hepatocellular carcinomas (HCCs) was enrolled as the first patient in a pilot study for treating multiple liver tumors with boron neutron capture therapy (BNCT). Because of compromised liver function, the multiple tumors in the right liver lobe were treated with BNCT and those in the left lobe with hepatic arterial chemoembolization. The feasibility and clinical outcome of this first case was assessed. During the treatment and follow-up period, no adverse effect as a result of BNCT was observed except for temporary temperature elevation to 38.3°C, and the AST and ALT being higher than 200 IU/l. For 1 month, the tumors treated with BNCT remained stable in size. The BNCT-treated tumors showed regrowth 3.5 months after BNCT and the patient died of liver dysfunction caused by progression of HCC 10 months after BNCT. The feasibility of BNCT for HCC is confirmed in this first case.

Key Words: boron neutron capture therapy • hepatocellular carcinoma • liver tumors


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