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Japanese Journal of Clinical Oncology 2008 38(1):2-7; doi:10.1093/jjco/hym157
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© The Authors (2008). Published by Oxford University Press. All rights reserved

Plasma Levels of Prothrombin Fragment F1+2, D-dimer and Prothrombin Time Correlate with Clinical Stage and Lymph Node Metastasis in Operable Gastric Cancer Patients

Hyuk-Chan Kwon1, Sung Yong Oh1, Suee Lee1, Sung-Hyun Kim1, Jin Yeong Han2, Ri Young Koh2, Min Chan Kim3 and Hyo-Jin Kim1,

1 Departments of Internal Medicine, Surgery, Dong-A University College of Medicine, Busan, South Korea
2 Departments of Internal Medicine, Laboratory Medicine, Surgery, Dong-A University College of Medicine, Busan, South Korea
3 Departments of Internal Medicine, Surgery, Dong-A University College of Medicine, Busan, South Korea

For reprints and all correspondence: Hyo-Jin Kim, Department of Internal Medicine, Dong-A University College of Medicine, 3-1 Dongdaeshin-dong, Seo-gu, Busan 602-715, South Korea. E-mail: kimhj{at}dau.ac.kr

Received July 4, 2007; accepted October 23, 2007

Objective: The principal objective of this study was to determine the relationship between preoperative coagulation tests and the extent of tumor involvement in gastric cancer patients.

Method: A total of 110 patients with adenocarcinoma of the stomach were studied in order to evaluate this relationship. Platelet count (P), prothrombin time (PT), activated partial thromboplastin time, D-dimer, fibrinogen degradation product, thrombin–antithrombin complex and prothrombin fragment F1+2 (F1+2) were evaluated.

Results: The D-dimer levels were positively correlated with the depth of invasion (P =0.007). Plasma D-dimer and PT were highly correlated with degree of lymph node involvement (P = 0.006, 0.004, respectively). D-dimer level, PT and plasma F1+2 level were correlated with clinical stage (P = 0.001, 0.017, 0.031, respectively). PT and F1+2 levels were significant in the prediction of the presence of lymph node involvement on the multivariate logistic regression models (odds ratio 2502.081 (5.977–1047425.4); P = 0.010 and odds ratio 19.487 (1.495–253.936); P = 0.023, respectively).

Conclusion: PT and plasma levels of F1+2 and D-dimer could be markers of degree or presence of lymph node involvement and clinical stage in patients with operable gastric cancer.

Key Words: coagulation test • gastric cancer


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