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Japanese Journal of Clinical Oncology Advance Access originally published online on January 17, 2008
Japanese Journal of Clinical Oncology 2008 38(1):31-35; doi:10.1093/jjco/hym135
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© The Author (2008). Published by Oxford University Press. All rights reserved

Prognostic Value of Surgical Margin Status for Biochemical Recurrence Following Radical Prostatectomy

Kohei Hashimoto1, Naoya Masumori1,, Fumiyasu Takei1, Fumimasa Fukuta1, Atsushi Takahashi3, Naoki Itoh1, Tadashi Hasegawa2 and Taiji Tsukamoto1

1 Department of Urology, Hakodate, Hokkaido, Japan
2 Department of Surgical Pathology, Sapporo Medical University School of Medicine, Sapporo, Hakodate, Hokkaido, Japan
3 Department of Urology, Hakodate Goryokaku Hospital, Hakodate, Hokkaido, Japan

For reprints and all correspondence: Naoya Masumori, Department of Urology, Sapporo Medical University School of Medicine, S1, W16, Chuo-ku, Sapporo 060-8543, Japan. E-mail: masumori{at}sapmed.ac.jp

Received June 4, 2007; accepted September 19, 2007

Objective: We evaluated the preoperative parameters to predict a positive surgical margin (SM) at radical prostatectomy for patients with prostate cancer. In addition, the prognostic factors for biochemical recurrence were determined in patients with positive SMs.

Methods: We retrospectively analysed 238 patients with prostate cancer who underwent retropubic radical prostatectomy and bilateral pelvic lymph node dissection from May 1985 to July 2005 in our hospital. Biochemical recurrence was defined as an increase of undetectable prostate-specific antigen (PSA) to 0.2 ng/ml or greater.

Results: Of the 238, 82 patients (34.4%) had positive SMs. On multivariate analysis, preoperative PSA (≥10 ng/ml), clinical T stage (≥T2a) and the positive core rate (≥35%) were parameters that could predict a positive SM. During the median follow-up of 31.2 months, 48 patients (20.2%) developed biochemical recurrence. The 5-year biochemical progression-free survival rates were 81.7% and 62.6% in patients with negative and positive SMs, respectively (P < 0.001). In the Cox proportional hazards model, preoperative PSA of ≥20 ng/ml and a pathological T stage of pT3a/pT3b were significant risk factors for biochemical recurrence in patients with positive SMs.

Conclusions: SM status at radical prostatectomy depends on preoperative PSA, clinical stage and the positive core rate. Patients with a positive SM had a higher risk for biochemical recurrence than those with a negative one. Patients with a positive margin had a higher risk for biochemical recurrence if they exhibited preoperative PSA of ≥20 ng/ml and/or pathological T stage of pT3a/pT3b.

Key Words: prostate cancer • radical prostatectomy • surgical margin • recurrence


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