Skip Navigation


Japanese Journal of Clinical Oncology Advance Access originally published online on October 24, 2008
Japanese Journal of Clinical Oncology 2008 38(12):857-860; doi:10.1093/jjco/hyn110
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow All Versions of this Article:
38/12/857    most recent
hyn110v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Request Permissions
Google Scholar
Right arrow Articles by Nozaki-Taguchi, N.
Right arrow Articles by Shimoyama, N.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Nozaki-Taguchi, N.
Right arrow Articles by Shimoyama, N.
Related Collections
Right arrow Case Report
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?


© The Author (2008). Published by Oxford University Press. All rights reserved

Potential Utility of Peripherally Applied Loperamide in Oral Chronic Graft-versus-host Disease Related Pain

Natsuko Nozaki-Taguchi1, Mariko Shutoh2 and Naohito Shimoyama2

1 Department of Anesthesiology and Palliative medicine, Chiba University Graduate School of Medicine, Chiba
2 Department of Anesthesiology and Palliative medicine, National Cancer Center Hospital, Tokyo, Japan

For reprints and all correspondence: Natsuko Nozaki-Taguchi, Department of Anesthesiology and Palliative medicine, Chiba University Graduate School of Medicine, 1-8-1 Inohana, Chuo, Chiba 260-8677, Japan. E-mail: nnoztag{at}faculty.chiba-u.jp

Received June 18, 2008; accepted September 16, 2008

Four patients with oral chronic graft-versus-host disease pain were treated with loperamide oral-rinse solution. Two-week continued use of the drug solution improved not only the pain scores but also the pain-causing disabilities associated with eating, drinking and sleeping, with no noticeable side effects. Current results suggest that the mu-opioid agonist, loperamide, has a potential analgesic effect that could be clinically used as a peripheral analgesic agent for stomatits pain. However, these observations will need to be further confirmed in a randomized-controlled trial.

Key Words: loperamide • chronic graft-versus-host disease • stomatitis


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.