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Japanese Journal of Clinical Oncology Advance Access originally published online on October 19, 2008
Japanese Journal of Clinical Oncology 2008 38(12):861-866; doi:10.1093/jjco/hyn111
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© The Author (2008). Published by Oxford University Press. All rights reserved

Association of Transforming Growth Factor-beta 1 Polymorphisms with Genetic Susceptibility to TNM Stage I or II Gastric Cancer

Pin Zhang1,*, Jian-Zhong Di1,*, Zhong-Zheng Zhu2, Hui-Min Wu3, Yu Wang1, Guanshan Zhu4, Qi Zheng1 and Lifang Hou5

1 Department of General Surgery, The Sixth People’s Hospital, Shanghai Jiaotong University, Shanghai
2 Department of Pathology, No. 113 Hospital of People’s Liberation Army, Ningbo
3 Department of General Surgery, Tongji hospital, Tongji University, Shanghai
4 Shanghai GeneCore Biotechnologies Co., Ltd, Shanghai, China
5 Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA

For reprints and all correspondence: Yu Wang, Department of General Surgery, The Sixth People's Hospital, Shanghai Jiaotong University, No. 600 Yishan Road, 200233 Shanghai, China. E-mail: wangyudjz{at}126.com

Received August 24, 2008; accepted September 18, 2008

Transforming growth factor-beta 1 (TGF-β1) inhibits the proliferation of tumors in early stages of cancers, whereas it promotes tumor growth and metastasis in later stages of cancers. To examine the effect of the TGF-β1 polymorphisms on gastric cancer risk, we studied the association between C–509T and T+29C (Leu10Pro) polymorphisms in TGF-β1 and gastric cancer risk in 414 cases and 414 controls in the Chinese population. When the overall gastric cancer cases were compared with the controls, no significant difference was found in genotype distributions for both the polymorphisms examined. However, when stratified by tumor stage, the –509T and +29C allele carriers had a 0.57-fold (95% CI = 0.36–0.90) and a 0.58-fold (95% CI = 0.36–0.91) decreased risk of TNM stage I+II gastric cancer, respectively, as compared with non-carriers. We conclude that TGF-β1–509T and +29C alleles may have a protective role in the development of stage I+II gastric cancer.

Key Words: TGF-β1 • gastric cancer • single nucleotide polymorphism • genetic susceptibility

* These two authors contributed equally to the work.


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