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Japanese Journal of Clinical Oncology Advance Access originally published online on February 1, 2008
Japanese Journal of Clinical Oncology 2008 38(2):140-142; doi:10.1093/jjco/hym166
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© The Authors (2008). Published by Oxford University Press. All rights reserved

Pseudoprogression of Lung Cancer after Concomitant Chemoradiotherapy

Eiki Ichihara1, Katsuyuki Kiura1,, Nagio Takigawa1, Masako Omori2, Motoi Aoe3, Mitsune Tanimoto1 and Hiroshi Date3

1 Department of Hematology, Oncology and Respiratory Medicine, Okayama, Japan
2 Department of Pathology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan
3 Department of Cancer and Thoracic Surgery, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan

For reprints and all correspondence: Katsuyuki Kiura, Department of Hematology, Oncology and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata, Okayama, Okayama 700-8558, Japan. E-mail: kkiura{at}md.okayama-u.ac.jp

Received July 17, 2007; accepted November 21, 2007

We observed re-enlargement of a squamous cell carcinoma without recurrence. The tumour regressed markedly after concomitant chemoradiotherapy, but within 1 month, we supposed that the tumour had enlarged again and resection was performed. The resected tissue showed evidence of haemorrhage and several lymphocytes and macrophages, but no malignant cells were detected. We herein report a rare case of lung cancer showing a pathological complete response despite re-enlargement of tumour lesion.

Key Words: lung cancer • pseudoprogression • complete response • haemorrhage • necrosis


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