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Japanese Journal of Clinical Oncology Advance Access originally published online on July 9, 2008
Japanese Journal of Clinical Oncology 2008 38(7):504-506; doi:10.1093/jjco/hyn058
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© The Author (2008). Published by Oxford University Press. All rights reserved

Randomized Controlled Trial Comparing Gastrectomy Plus Chemotherapy with Chemotherapy Alone in Advanced Gastric Cancer with A Single Non-curable Factor: Japan Clinical Oncology Group Study JCOG 0705 and Korea Gastric Cancer Association Study KGCA01

Kazumasa Fujitani1, Han-Kwang Yang2, Yukinori Kurokawa1, Do Joong Park3, Toshimasa Tsujinaka1, Byung-Joo Park4, Haruhiko Fukuda5, Sung Hoon Noh6, Narikazu Boku7, Yung-Jue Bang8, Mitsuru Sasako9, Jong-Inn Lee10 for the Gastric Cancer Surgical Study Group of Japan Clinical Oncology Group and Korea Gastric Cancer Association

1 Department of Surgery, National Osaka Medical Center, Osaka, Japan
2 Department of Surgery, Cancer Research Institute, Seoul National University
3 Department of Surgery, Seoul National University Bundang Hospital
4 Department of Preventive Medicine, Seoul National University, Seoul, Republic of Korea
5 Center for Cancer Control and Information Services, National Cancer Center, Tokyo, Japan
6 Department of Surgery, Yonsei University Severance Hospital, Seoul, Republic of Korea
7 Department of Gastrointestinal Oncology, Shizuoka Cancer Center, Shizuoka, Japan
8 Department of Medical Oncology, Seoul National University, Seoul, Republic of Korea
9 Department of Surgery, Hyogo Medical College, Hyogo, Japan
10 Department of Surgery, Korea Cancer Center, Seoul, Republic of Korea

For reprints and all correspondence: Kazumasa Fujitani, Department of Surgery, National Osaka Medical Center, 2-1-14 Hoenzaka, Chuo-ku, Osaka 540-0006, Japan. E-mail: fujitani{at}onh.go.jp

Received March 15, 2008; accepted June 10, 2008

A randomized controlled trial has started in both Japan and Korea to evaluate the role of gastrectomy in the management of incurable advanced gastric cancer (AGC). Patients with AGC diagnosed as having a single non-curable factor are randomized to gastrectomy plus chemotherapy or chemotherapy alone. Surgeons at 33 specialized centers in Japan and at 15 high-volume hospitals in Korea will recruit 330 patients. Primary end-point is overall survival, and secondary end-points are progression-free survival and adverse events associated with either gastrectomy or chemotherapy.

Key Words: gastrectomy • chemotherapy • advanced gastric cancer • non-curable factor • randomized controlled trial


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