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Japanese Journal of Clinical Oncology Advance Access originally published online on August 7, 2008
Japanese Journal of Clinical Oncology 2008 38(9):626-633; doi:10.1093/jjco/hyn075
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© The Author (2008). Published by Oxford University Press. All rights reserved

Genetic Variants in T Helper Cell Type 1, 2 and 3 Pathways and Gastric Cancer Risk in a Polish Population

Rajeev Mahajan1, Emad M. El-Omar2, Jolanta Lissowska3, Paolo Grillo4, Charles S. Rabkin1, Andrea Baccarelli4, Meredith Yeager5, Leslie H. Sobin6, Witold Zatonski3, Stephen J. Channock1,5, Wong-Ho Chow1 and Lifang Hou1,7

1 Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD
2 Department of Medicine and Therapeutics, Institute of Medical Sciences, University of Aberdeen, Aberdeen, UK
3 Division of Cancer Epidemiology and Prevention, Cancer Centre and M. Sklodowska-Curie Institute of Oncology, Warsaw, Poland
4 EPOCA Epidemiology Research Centre, Maggiore Hospital IRCCS Foundation, University of Milan, Milan, Italy
5 Core Genotyping Facility, Advanced Technology Center, National Cancer Institute, Gaithersburg, MD
6 Division of Gastrointestinal Pathology, Armed Forces Institute of Pathology, Washington, DC
7 Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA

For reprints and all correspondence: Lifang Hou, Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, 680 N Lake Shore Drive, Chicago, IL 60611, USA. E-mail: l-hou{at}northwestern.edu

Received April 19, 2008; accepted July 16, 2008

Host immune responses are known determinants of gastric cancer susceptibility. We previously reported an increased gastric cancer risk associated with common variants of several T helper type 1 (Th1) cytokine genes in a population-based case–control study in Warsaw, Poland. In the present study, we augmented our investigation to include additional Th1 genes as well as key genes in the Th2 and Th3 pathways. Analysis of 378 cases and 435 age- and sex-matched controls revealed associations for polymorphisms in the Th1 IL7R gene and one polymorphism in the Th2 IL5 gene. The odd ratios (ORs) for IL7R rs1494555 were 1.4 [95% confidence interval (CI), 1.0–1.9] for A/G and 1.5 (95% CI, 1.0–2.4) for G/G carriers relative to A/A carriers (P = 0.04). The ORs for IL5 rs2069812 were 0.9 (95% CI, 0.7–1.3) for C/T and 0.6 (95% CI, 0.3–1.0) T/T carriers compared with C/C carriers (P = 0.03). These results suggest that IL5 rs2069812 and IL7R rs1389832, rs1494556 and rs1494555 polymorphisms may contribute to gastric cancer etiology.

Key Words: gastric cancer • T helper cell pathways • polymorphism


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