Skip Navigation

Japanese Journal of Clinical Oncology 2009 39(10):625-631; doi:10.1093/jjco/hyp094
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Request Permissions
Google Scholar
Right arrow Articles by Liu, C.
Right arrow Articles by Wu, N.
PubMed
Right arrow PubMed Citation
Right arrow Articles by Liu, C.
Right arrow Articles by Wu, N.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?


© The Author (2009). Published by Oxford University Press. All rights reserved

Expression Pattern and Clinical Prognostic Relevance of Bone Morphogenetic Protein-2 in Human Gliomas

Ce Liu1{dagger}, Gang Tian2,{dagger}, Yanyang Tu3, Jianfang Fu4, Chuan Lan2 and Nan Wu2

1 Department of Neurosurgery, The Second Affiliated Hospital of the General Hospital of the People's Liberation Army, Beijing
2 Department of Neurosurgery, Southwest Hospital, The Third Military Medical University, Chongqing
3 Department of Neurosurgery, 63870 Hospital of the People's Liberation Army
4 Department of Endocrine Secretion, Xijing Hospital of the Fourth Military Medical University, Shanxi, PR China

For reprints and all correspondence: Nan Wu, Department of Neurosurgery, Southwest Hospital, The Third Military Medical University, Chongqing 400038, PR China. E-mail: ctyliu{at}gmail.com

Received April 27, 2009; accepted July 13, 2009

Objective: Bone morphogenetic protein-2 (BMP-2) is normally expressed in the embryo promoting the development of several organs. Aberrant expression of BMP-2 occurs in various tumors. However, a correlation between BMP-2 expression in human gliomas and patients' prognosis has not been reported. To address this question, this study was to investigate the BMP-2 expression pattern in human gliomas and to evaluate its prognostic relevance.

Methods: We analyzed the expression of the BMP-2 antigen in a series of 98 gliomas of various grade and histology by immunohistochemistry on paraffin-embedded sections. Then, the correlation of BMP-2 expression pattern with clinical–pathological features of patients and its prognostic relevance were determined.

Results: Immunohistochemical analysis with anti-BMP-2 antibody revealed dense and spotty staining in the tumor cells and its expression levels became significantly higher as the gliomas' grade advanced (P < 0.001). The median survival of patients with intensively positive BMP-2 expression was significantly shorter than that with negative expression (318 vs. 1197 days, P < 0.0001). The Kaplan–Meier survival curves showed that the BMP-2 expression was not only a significant predictor of survival in high-grade gliomas (grade IV, P = 0.02), but also in lower-grade gliomas (grades II and III, P < 0.001).

Conclusions: These results indicate that BMP-2 is a highly sensitive marker for gliomas prognosis and suggest that the expression level of BMP-2 may be a potent tool for the clinical prognosis of gliomas patients.

Key Words: bone morphogenetic protein-2 • glioma • prognosis

{dagger} Contribute equally to this work.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.