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Japanese Journal of Clinical Oncology Advance Access originally published online on August 12, 2009
Japanese Journal of Clinical Oncology 2009 39(11):727-731; doi:10.1093/jjco/hyp091
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© The Author (2009). Published by Oxford University Press. All rights reserved

PSA Doubling Time as a Predictive Factor on Repeat Biopsy for Detection of Prostate Cancer

Masashi Shimbo1, Susumu Tomioka1, Makoto Sasaki1, Takayuki Shima1, Noriyuki Suzuki1, Shino Murakami1, Hiroomi Nakatsu1 and Jun Shimazaki2

1 Department of Urology, Asahi General Hospital, Asahi
2 Department of Urology, Graduate School of Medicine, Chiba University, Chiba, Japan

For reprints and all correspondence: Jun Shimazaki, Department of Urology, Graduate School of Medicine, Chiba University, Inohana, Chuo-ku, Chiba-shi 260-8670, Japan. E-mail: shimajun{at}opal.famille.ne.jp

Received March 5, 2009; accepted July 12, 2009

Objective: Detection of prostate cancer needs a biopsy of the prostate. Suspecting cancer from an increase in prostate-specific antigen (PSA) has a high negative rate at an initial prostate biopsy. Cases with negative initial biopsy may be the candidates of subsequent biopsy. For lowering unnecessary repeat biopsy, the use of predictive factors before a repeat biopsy is applied for indication.

Methods: Seventy-seven cases with negative initial prostate biopsy received a repeat biopsy and factors for the detection of cancer were examined.

Results: PSA doubling time distinguished a part of cancer cases. Its sensitivity of 30, 50 and 70 months was 36.6%, 30.4% and 10%, respectively. Cancer case did not show PSA doubling time of >100 months in general. Values of PSA transition zone density, %Free/total PSA and PSA velocity were similar between cancer and no cancer cases.

Conclusions: PSA doubling time was one of the predictive factors for the detection of prostate cancer and was valuable for avoiding unnecessary repeat biopsy in some cases.

Key Words: prostate cancer • biopsy • predictive factor • PSA doubling time


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