Skip Navigation


Japanese Journal of Clinical Oncology Advance Access originally published online on January 8, 2009
Japanese Journal of Clinical Oncology 2009 39(3):186-188; doi:10.1093/jjco/hyn145
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow All Versions of this Article:
39/3/186    most recent
hyn145v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Request Permissions
Google Scholar
Right arrow Articles by Yamanaka, T.
Right arrow Articles by Nakano, T.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Yamanaka, T.
Right arrow Articles by Nakano, T.
Related Collections
Right arrow Clinical Trial Note
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?


© The Author (2009). Published by Oxford University Press. All rights reserved

A Feasibility Study of Induction Pemetrexed Plus Cisplatin Followed by Extrapleural Pneumonectomy and Postoperative Hemithoracic Radiation for Malignant Pleural Mesothelioma

Takeharu Yamanaka1, Fumihiro Tanaka2, Seiki Hasegawa2, Morihito Okada3, Toshinori Soejima4, Norihiko Kamikonya5, Kazuya Fukuoka6 and Takashi Nakano6

1 Institute for Clinical Research, National Kyushu Cancer Center, Fukuoka
2 Department of Thoracic Surgery, Hyogo Cancer Center, Hyogo
3 Department of Surgical Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima
4 Department of Radiation Oncology, Hyogo Cancer Center, Hyogo
5 Department of Radiation Oncology, Hyogo College of Medicine, Hyogo
6 Division of Respiratory Medicine, Department of Internal Medicine, Hyogo College of Medicine, Hyogo, Japan

For reprints and all correspondence: Takashi Nakano, Division of Respiratory Medicine, Department of Internal Medicine, Hyogo College of Medicine, 1-1 Mukogawa, Nishinomiya, Hyogo 663-8501, Japan. E-mail: t-nakano{at}hyo-med.ac.jp

Received July 14, 2008; accepted November 30, 2008

A prospective multi-institutional study has been commenced in Japan to evaluate the feasibility of induction chemotherapy using pemetrexed plus cisplatin, followed by extrapleural pneumonectomy (EPP) and postoperative hemithoracic radiation in patients with resectable malignant pleural mesothelioma. The study was initiated on May 2008 and 40 patients will be recruited over 3 years. Primary endpoints are macroscopic complete resection rate by EPP and treatment-related mortality for trimodality therapy. Secondary endpoints include treatment completion rate, adverse events, response rate by chemotherapy and 2-year overall and relapse-free survival.

Key Words: extrapleural pneumonectomy • induction chemotherapy • radiotherapy • malignant pleural mesothelioma


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.