Skip Navigation


Japanese Journal of Clinical Oncology Advance Access originally published online on April 9, 2009
Japanese Journal of Clinical Oncology 2009 39(6):394-398; doi:10.1093/jjco/hyp026
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
39/6/394    most recent
hyp026v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Request Permissions
Google Scholar
Right arrow Articles by Miyagawa, T.
Right arrow Articles by Akaza, H.
PubMed
Right arrow PubMed Citation
Right arrow Articles by Miyagawa, T.
Right arrow Articles by Akaza, H.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?


© The Author (2009). Published by Oxford University Press. All rights reserved

Real-time Elastography for the Diagnosis of Prostate Cancer: Evaluation of Elastographic Moving Images

Tomoaki Miyagawa1, Masakazu Tsutsumi2, Takeshi Matsumura3, Natsui Kawazoe2, Satoru Ishikawa2, Tatsuro Shimokama4, Naoto Miyanaga5 and Hideyuki Akaza5

1 Department of Urology, Kitaibaraki Municipal General Hospital, Ibaraki
2 Department of Urology, Hitachi General Hospital, Hitachi City, Ibaraki
3 Ultrasound Systems Division, Hitachi Medical Corporation, Kashiwa City, Chiba
4 Department of Pathology, Hitachi General Hospital
5 Department of Urology, Institute of Clinical Medicine, University of Tsukuba, Ibaraki, Japan

For reprints and all correspondence: Tomoaki Miyagawa, Department of Urology, Kitaibaraki Municipal General Hospital, 4-5-15 Ohtsu-cho, Kita-cho, Kita-Ibaraki City, Ibaraki, Japan. E-mail sh-miya{at}umin.ac.jp

Received January 12, 2009; accepted March 5, 2009

Objective: Elastography is a technique for detecting the stiffness of tissues. We applied elastography for the diagnosis of prostate cancer and evaluated the usefulness of elastography for prostate biopsy.

Methods: The subjects of this study were 311 patients who underwent elastography during prostate needle biopsy at Hitachi General Hospital. Strain images obtained during compression of the prostate tissue were displayed on a monitor and recorded on the computer. The elastographic moving images (EMI) were evaluated retrospectively. The evaluable images and biopsy results were compared in terms of the feasibility and accuracy.

Results: The median patient age was 67 years (range 50–85 years), the median serum level of prostate-specific antigen was 8.4 ng/ml (range 0.3–82.5 ng/ml) and the median prostate volume was 42.6 ml (range 12–150 ml). Among the 311 patients, prostate cancer was detected in 95 patients (30%) by biopsy. The diagnostic sensitivity was 37.9% for digital rectal examination (DRE) and 59.0% for transrectal ultrasonography (TRUS), whereas it was 72.6% for elastography and 89.5% for the combination of TRUS and elastography. Elastography-positive EMIs with negative biopsies were eventually determined to be due to benign prostatic hyperplasia.

Conclusion: Elastography has a significantly higher sensitivity for the detection of prostate cancer than the conventionally used examinations including DRE and TRUS. It is a useful real-time diagnostic method because it is not invasive, and simultaneous evaluation is possible while performing TRUS.

Key Words: prostate cancer • screening • prostate-specific antigen • transrectal • ultrasonography • elastography


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.