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Japanese Journal of Clinical Oncology Advance Access originally published online on June 9, 2009
Japanese Journal of Clinical Oncology 2009 39(8):497-501; doi:10.1093/jjco/hyp056
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© The Author (2009). Published by Oxford University Press. All rights reserved

No Association of the NFKB1 Insertion/Deletion Promoter Polymorphism with Survival in Patients with Gastric Cancer

Jong Gwang Kim1, Sang Kyun Sohn1, Yee Soo Chae1, Joon Ho Moon1, Shi Nae Kim1, Byung Woog Kang1, Gab Chul Kim2, Myung-Hoon Lee3, Seong Woo Jeon4, Ho Young Chung5 and Wansik Yu5

1 Department of Oncology/Hematology, Kyungpook National University Hospital, Kyungpook National University School of Medicine
2 Department of Radiology, Kyungpook National University Hospital, Kyungpook National University School of Medicine
3 Department of the Advanced Medical Technology Center for Diagnosis and Prediction, Kyungpook National University Hospital, Kyungpook National University School of Medicine
4 Department of Internal Medicine, Kyungpook National University Hospital, Kyungpook National University School of Medicine
5 Department of Surgery, Kyungpook National University Hospital, Kyungpook National University School of Medicine, Daegu, Korea

For reprints and all correspondence: Wansik Yu, Department of Surgery, Kyungpook National University Hospital, Kyungpook National University School of Medicine, 50 Samduck 2-Ga, Jung-Gu, Daegu 700-712, Korea. E-mail: wyu{at}mail.knu.ac.kr

Received February 27, 2009; accepted May 4, 2009

Objective: The present study analyzed the functional insertion/deletion polymorphism in the promoter region of NFKB1 gene and their impact on the prognosis for patients with gastric adenocarcinoma.

Methods: Four hundred and seventy two consecutive patients with curatively resected gastric adenocarcinoma were enrolled in the present study. The genomic DNA was extracted from paraffin-embedded tissue and the –94 insertion/deletion ATTG polymorphism of NFKB1 determined using a polymerase chain reaction–restriction fragment length polymorphism assay.

Results: The NFKB1 promoter gene polymorphism was successfully amplified in 97.8% of the cases. There were no sexual differences in relation to the genotype and allele. No correlation was observed between the frequency of the genotype or allele and the T, N or M stage. The multivariate survival analysis showed no association between the NFKB1 –94 insertion/deletion promoter polymorphism and the disease-free survival or overall survival of the patients with gastric cancer.

Conclusions: The functional NFKB1 promoter polymorphism was not found to be a prognostic marker for Korean patients with surgically resected gastric adenocarcinoma.

Key Words: gastric cancer • NFKB1 • polymorphism • prognosis


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