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Japanese Journal of Clinical Oncology 7:73-84 (1977)
© 1977 Foundation for Promotion of Cancer Research

research-article

Cytodifferentiation to Serous and Myoepithelial Cells in Salivary Gland and Salivary Gland Type Tumors

TORU KAMEYA, M.D., YUKIO SHIMOSATO, M.D., TOSHIYUKI TAKEUCHI, M.D. and SHUICHI SASADAIRA, Ph.D.*

Pathology and Biochemistry Divisions, National Cancer Centei Research Institute Tokyo Japan

Reprint requests: Toru Kameya, M.D., Pathology Division, National Cancer Center Research institute, 5-1-1, Tsukiji, Chuo-ku, Tokyo, Japan.

Received October 31, 1977; Three-hundred-and-three cases of salivary gland and salivary gland type tumors in the head and neck and lower respiratory tract, treated in our institution, were reviewed histologically. Some of these cases were analyzed; 51 arbitrarily selected cases by conventional stainings, 15 cases by immunostainings for amylase and actomyosin, and 22 cases by electron microscopy for cellular differentiation to serous and myoepithelial cells For morphological and biochemical comparison, six cases of ectopic amylase-producing tumor were also studied Serous acmar cells contained amylase and basaly located cells of acini and ducts contained actomyosin in non-neoplastic salivary glands Although zymogen type granules were barely observed except in a case of acinic cell carcinoma of the palate and in a case of adenocarcinoma of the lung by light and electron microscopy, some tumor cells contained amylase which seemed to be specific of salivary gland tumor in three cases and of ectopic amylase-producing tumor in three cases, confirmed by immunofluorescent microscopy, enzyme assay and electrophoresis of the tumor tissues

In cases of mixed tumor, adenoid cystic carcinoma, and mucoepidermoid carcinoma, cells reactive to anti-actomyosin were often encountered in the outer layer of duct-like structures

By electron microscopy, location of myoepithelium-like cells was in accord-ance with that of actomyosin-positive cells in some instances Coexistence of tonofibrils and myofilaments in one and the same cell was occasionally seen

* Present address: Department of Pathology, Tokai University School of Medicine, Kana gawa, Japan.


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