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Japanese Journal of Clinical Oncology 9:209-214 (1979)
© 1979 Foundation for Promotion of Cancer Research

research-article

Effect of Long-Term Administration of OK-432 (Picibanil), PS-K (Krestin) and Levamisole on Immune Responses in Aged Subjects Without Malignancy

NOBUYOSHI YOKOE, M.D., HARUKI KATO, M.D., SHUHEI TAKEMURA, M.D., TOSHIKAZU YOSHIKAWA, M.D., MOTOHARU KONDO, M.D., KEIMEI HOSOKAWA, M.D.* and MASASHI KODAMA, M.D.**

First Department of Medicine, Kyoto Prefectural University of Medicine Kyoto
*Third Department of Medicine, Kyoto Prefectural University of Medicine Kyoto
**Second Department of Surgery, Kyoto Prefectural University of Medicine Kyoto

Received June 8, 1979; So-called immunomodulators, streptococcal preparation OK-432 (Pici-banil), protein polysaccharide PS-K (Krestin) and anthelminthic compound Levamisole, were investigated for their ability to restore the decreased immune responses in aged patients without malignancy. These immunomodulators exerted their effect on host-immune responses during six months of therapy, as determined by the Mantoux skin test, the phytohemagglutinin skin test, the endotoxin skin test and in vitro blastoid transformation of lymphocytes.


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