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Japanese Journal of Clinical Oncology 9:215-224 (1979)
© 1979 Foundation for Promotion of Cancer Research

research-article

Immunohistochemical and Clinical Study of hCG-Producing Tumors

TADAO OKANO, M.D.

First Department of Pathology, Nihon University School of Medicine Tokyo

Received July 23, 1979; Immunohistochemical techniques were used to detect human chorionic gonadotropin (hCG) immunoreactive cells in pulmonary carcinoma, mediastinal tumors, gastric carcinoma, pancreatic tumors, pineal choriocarcinoma, intestinal carcinoma, renal cell carcinoma, pheochromocytoma and testicular tumors. Thirty-four cases (20.9%) with various tumors showed hCG immunoreactivity in the cytoplasm of the tumor cells. Patients with trophoblastic tumors usually showed gynecomastia and the other characteristic clinical symptoms and high serum and/or hCG urinary values. The ability of tumor cells to produce hCG was dependent on the histological type of the tumors rather than their origin. The germ cell tumors, especially the choriocarcinoma variety, showed strong immunostaining of hCG, indicating a high level of hCG in the cytoplasm. The variable intensity in immunostaining in the same tumor tissue is thought to represent the functional state of the individual tumor cell in the production and secretion of hCG. APUDomas including small cell carcinoma of the lung, pancreatic islet cell tumors and pheochromocytoma contained hCG-positive cells, indicating a latent ability for hCG production.


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