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Japanese Journal of Clinical Oncology Advance Access published online on January 3, 2007
Japanese Journal of Clinical Oncology, doi:10.1093/jjco/hyl122
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© 2007 Foundation for Promotion of Cancer Research

Current Trends and Controversies over Pre-operative Chemotherapy for Women with Operable Breast Cancer

Chikako Shimizu, Masashi Ando, Tsutomu Kouno, Noriyuki Katsumata and Yasuhiro Fujiwara

Division of Breast and Medical Oncology, National Cancer Center Hospital, Tokyo, Japan

For reprints and all correspondence: Yasuhiro Fujiwara, Division of Breast and Medical Oncology, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan. E-mail: yfujiwar{at}ncc.go.jp

Received June 24, 2006; accepted September 18, 2006

The multi-disciplinary approach, including surgery, chemotherapy, endocrine therapy and radiation therapy, has become the standard treatment for primary breast cancer patients. The indication of pre-operative chemotherapy has been extended to women with potentially operable breast cancer based on the results of large randomized studies and has become an attractive option that extends the chance of breast conservation. The clinical and pathological responses to pre-operative chemotherapy correlates with long-term outcome. The anthracycline-containing regimen is now considered the standard. Sequential administration of non-cross-resistant drugs, namely taxanes, improves local tumor response but its long-term benefit has been controversial. Prediction of response to pre-operative chemotherapy still remains a challenge. Identification of useful predictive markers and development of molecular-targeted drugs is the key to individualized therapy in the future.

Key Words: pre-operative chemotherapy • breast cancer • advantage • response • long-term outcome • prediction


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