Skip Navigation



Japanese Journal of Clinical Oncology Advance Access published online on January 17, 2008
Japanese Journal of Clinical Oncology, doi:10.1093/jjco/hym135
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow All Versions of this Article:
38/1/31    most recent
hym135v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Request Permissions
Google Scholar
Right arrow Articles by Hashimoto, K.
Right arrow Articles by Tsukamoto, T.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Hashimoto, K.
Right arrow Articles by Tsukamoto, T.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author (2008). Published by Oxford University Press. All rights reserved

Prognostic Value of Surgical Margin Status for Biochemical Recurrence Following Radical Prostatectomy

Kohei Hashimoto1, Naoya Masumori1,, Fumiyasu Takei1, Fumimasa Fukuta1, Atsushi Takahashi3, Naoki Itoh1, Tadashi Hasegawa2 and Taiji Tsukamoto1

1 Department of Urology
2 Department of Surgical Pathology, Sapporo Medical University School of Medicine, Sapporo
3 Department of Urology, Hakodate Goryokaku Hospital, Hakodate, Hokkaido, Japan

For reprints and all correspondence: Naoya Masumori, Department of Urology, Sapporo Medical University School of Medicine, S1, W16, Chuo-ku, Sapporo 060-8543, Japan. E-mail: masumori{at}sapmed.ac.jp

Received June 4, 2007; accepted September 19, 2007

Objective: We evaluated the preoperative parameters to predict a positive surgical margin (SM) at radical prostatectomy for patients with prostate cancer. In addition, the prognostic factors for biochemical recurrence were determined in patients with positive SMs.

Methods: We retrospectively analysed 238 patients with prostate cancer who underwent retropubic radical prostatectomy and bilateral pelvic lymph node dissection from May 1985 to July 2005 in our hospital. Biochemical recurrence was defined as an increase of undetectable prostate-specific antigen (PSA) to 0.2 ng/ml or greater.

Results: Of the 238, 82 patients (34.4%) had positive SMs. On multivariate analysis, preoperative PSA (≥10 ng/ml), clinical T stage (≥T2a) and the positive core rate (≥35%) were parameters that could predict a positive SM. During the median follow-up of 31.2 months, 48 patients (20.2%) developed biochemical recurrence. The 5-year biochemical progression-free survival rates were 81.7% and 62.6% in patients with negative and positive SMs, respectively (P < 0.001). In the Cox proportional hazards model, preoperative PSA of ≥20 ng/ml and a pathological T stage of pT3a/pT3b were significant risk factors for biochemical recurrence in patients with positive SMs.

Conclusions: SM status at radical prostatectomy depends on preoperative PSA, clinical stage and the positive core rate. Patients with a positive SM had a higher risk for biochemical recurrence than those with a negative one. Patients with a positive margin had a higher risk for biochemical recurrence if they exhibited preoperative PSA of ≥20 ng/ml and/or pathological T stage of pT3a/pT3b.

Key Words: prostate cancer • radical prostatectomy • surgical margin • recurrence


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.