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Japanese Journal of Clinical Oncology Advance Access originally published online on July 29, 2008
Japanese Journal of Clinical Oncology 2008 38(8):528-533; doi:10.1093/jjco/hyn065
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© The Author (2008). Published by Oxford University Press. All rights reserved

Clinicopathologic Evaluation of Immunohistochemical CD147 and MMP-2 Expression in Differentiated Thyroid Carcinoma

Hui Tan, Ke Ye, Zhiming Wang and Huihuan Tang

Department of General Surgery, Xiangya Hospital, Central South University, Changsha, China

For reprints and all correspondence: Huihuan Tang, Department of General Surgery, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China. E-mail: tanhui{at}medmail.com.cn

Received March 24, 2008; accepted June 24, 2008

Objective: CD147 is one of the molecules involved in regulating the expression of matrix metalloproteinases (MMPs). The goal of this study was to analyze the expression levels of CD147 and MMP-2 in differentiated thyroid carcinomas (DTCs) tissues, as well as their associations with the clinicopathologic features of DTC patients.

Methods: CD147 and MMP-2 expression in 156 patients who underwent operation for DTC (100 with papillary thyroid carcinomas and 56 with follicular thyroid carcinomas) were examined by immunostaining on paraffin-embedded tumor specimens. The Spearman correlation was calculated between the expression levels of CD147 and MMP-2 in DTC tissues. Then, the association of their expression with clinicopathologic characteristics was analyzed.

Results: CD147 and MMP-2 were expressed mainly in cancerous lesions, but also expressed in some normal tissues. A total of 55 and 58 in 156 (35.26 and 37.18%, respectively) cases showed low CD147- and MMP-2-positive expression; 52 and 50 in 156 (33.33 and 32.05%, respectively) cases showed intermediate CD147- and MMP-2-positive expression and 49 and 48 in 156 (31.41 and 30.77%, respectively) cases showed high CD147- and MMP-2-positive expression. The Spearman analysis indicated that the expression level of CD147 was positively correlated with that of MMP-2 significantly (rs = 0.86, P = 0.02). Positive CD147 and MMP-2 immunostaining associated significantly with extrathyroidal invasion (P = 0.02, 0.03), lymph node metastasis (P = 0.01, 0.01) and depth of tumor invasion (P < 0.01, =0.01).

Conclusions: The results have been demonstrated that the expression of CD147 and MMP-2 may be an important feature of DTC. The detection of these two markers may increase the ability of clinicians to investigate the progression of DTC patients.

Key Words: differentiated thyroid carcinoma • CD147 • MMP-2 • immunohistochemistry • clinicopathology


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